PVDF Cannula Filters, 35µm Pack of 100 with Yellow Micro-Spheres added for identification
Varian VanKel OEM No: 17-4050
Note: No Tygon tubing
needed -Direct fit cannula filters have been designed to fit directly onto the end of the standard VanKel style manual and automated cannula.
Vankel dissolution baths can use different filters. The -01 filters fit on the 3.6mm (0.0142") cannulae and also on the 2.1mm (0.083") cannulae with flexible tygon tubing (tubing increases the diameter to 3.6mm). If the tygon tubing is removed from the 2.1mm cannulae then 'direct fit' filters should be used.
- VanKel cannulae dimensions are larger than 3.2mm (1/8"). VanKel filters are not interchangeable with filters for other bath manufacturers.
- Filter tips offer an economical solution when only low flow rates and low particulate samples are taken. These will fit over the tygon tubing or 1/8” cannula.
- Note that VanKel was acquired by Varian and subsequently by Agilent.
Almost every dissolution test relies on samples being taken to produce a result. Filters are used to prevent particles of tablet from getting into the sample and affecting the spectrophotometer or HPLC results. Filters should be shown not to adsorb any compounds of interest.
Most manufacturers use a filter on the end of the sampling cannula. These cannula filters are made of UHMW Polyethylene for larger porosities or Poroplast for lower porosities (1-5μm) and are completely inert to most compounds.
With filters, porosities are nominal and represent an average pore size rather than an absolute pore size. Thus a 35μm and 40μm filter will perform in much the same way.
If in-line filters are used it is important that a small amount of media is pushed back in the reverse direction to wash particles off the filter back into the vessel. Particles are part of the tablet and as such should be kept inside the vessel dissolving with the rest of the tablet. Failure to do this results in the particles staying on the filter. The effect of this is not only to remove the particles from the media but next time a sample is taken, the media is pulled through the particles stuck to the filter which can give erroneously high readings.
When selecting a filter, it is wise to conduct some tests to ensure that there is no sample absorption onto the filter. If this is a problem then alternative filters and materials are available but external filtration may be required.
Types of Filter:
- Cannula Filters - Cannula Filters generally have a large surface area and may affect the hydrodynamics in the vessel. However they have a good flow rate and may be used when high levels of particulates are present to prevent particulates blocking the sample probes. A large porosity range is available. Different manufacturers recommend different filters for use with their sample probes and not all are interchangeable because of differences in probe diameter.
- Filter Discs - Some low volume sample probes require an In-Line Filter Disc (or filter frit) which has a lower surface area than a cannula filter. These are designed to keep the filtration process outside the vessel but may suffer from blocking due to the lower surface area. This problem can be solved with the Hi-Cap cannula which uses standard cannula filters outside the vessel.
- Filter Tips - Filter Tips are smaller than cannula filters and fit on the end of larger diameter sample probes.
- Model: FIL035-01K-100
- Manufactured by: QLA