Waters ACQUITY UPLC HSS Cyano (CN) Column, 100A, 1.8 um, 2.1 mm X 75 mm, 3/pkg - 176002708

Waters™ ACQUITY UPLC HSS Cyano (CN) Column, 100Å, 1.8 µm, 2.1 mm X 75 mm, 3/pkg

Product Number: 176002708

Specifications:

ACQUITY UPLC HSS CN chemistry is an ultra-performance general purpose propyl cyano bonded phase that provides superior peak shape for bases, increased retention, and extremely long column lifetimes at low pH. ACQUITY HSS CN columns are fully scalable and transferable to HPLC separations.

The ACQUITY UPLC HSS Cyano Column offers an extended pH range of 2 to 8, enabling reliable separations across a wide range of acidic and alkaline conditions.

To get exceptional peak shape and reproducibility in low- to mid-pH conditions, you need UPLC technology and a column that’s more than up for the task. That’s where the ACQUITY UPLC HSS Cyano (CN) Column comes into consideration. Thanks to the general-purpose propyl-cyano bonded phase, this cyano column offers superior peak shape for bases and increased retention of polar compounds. That balance between polar- and non-polar functionalities is achieved because of this column’s unique chemistry. What’s more, this ACQUITY UPLC Column is fully scalable and transferable to HPLC separations. That kind of flexibility has been desired by scientists everywhere, and we’re happy to deliver with the ACQUITY UPLC HSS CN Column.

The ACQUITY UPLC HSS Cyano Column was built with method development scientists in mind, as it can help you easily develop robust methods that are compatible with all modern chromatographic detection modes. To add to that flexibility, this CN column also offers low hydrophobicity and unique selectivity when compared to straight-chain alkyl columns. And thanks to the High-Strength Silica base particle, this column is able to achieve ultra-stable retention under demanding conditions. You need only look at the ACQUITY UPLC HSS Cyano Column’s pH range to see that’s true.

All ACQUITY UPLC Columns are classified by their terrific separation power and efficiency, but what else do they offer? For one, ACQUITY UPLC separation technology can help chromatographers harness the increased flow rates of UPLC and improve analyte sensitivity all at once. With more than 50 column dimensions and configurations in the ACQUITY UPLC family, you’re sure to find the right match for your LC-MS analyses.

With superior separation performance comes other considerations, though. To keep the ACQUITY UPLC HSS Cyano Column performing at its best, you need to follow proper column cleaning and regeneration directions. But if you’re using various chemicals and solvents in the same column, particulate fouling can become a concern. That’s why we recommend equipping your analytical column with an ACQUITY UPLC HSS Cyano (CN) VanGuard Pre-column. The pre-column threads easily into your analytical column for a seamless column protection workflow.

High Strength Silica (HSS) Particle Technology

To complement Waters revolutionary Hybrid Particle Technology (HPT), a mechanically tolerant, silica-based material was designed to withstand UPLC pressures. High Strength Silica (HSS) particle technology was born from an innovative synthetic prodcess that significantly increases the mechanical stability of silica while maintaining pore volumes similar to that of HPLC silica-based materials. The result is a novel particle technology that provides increased retentivity compared to hybrid particles while serving as the ideal substrate to create stationary phases that provide alternate selectivity,

ACQUITY UPLC HSS Cyano (CN) Columns

The ACQUITY UPLC HSS Cyano (CN) Columns provide low hydrophobicity and unique selectivity compared to straight-chain-alkyl columns. Due to the innovative monofunctional cyano bonding with protective alkyl-side chains, the ACQUITY UPLC HSS Cyano Column affords ultra-stable retention, exceptional peak shape and reproductibility under low to mid pH conditions. Additionally, the HSS Cyano column is compatible with both reversed-pase and normal-phase techniques. 

ACQUITY UPLC columns

ACQUITY UPLC columns are the most technologically advanced LC columns ever created and are the only columns designed, tested and certified to withstand the pressures of UPLC Technology. Based upon the highly efficient 1.7 µm Bridged Ethyl Hybrid (BEH) particles and 1.8 µm High Strength Silica (HSS) particles, these columns are the first and only columns that allow separation scientists to achieve maximum speed, sensitivity and resolution without compromise. The particles and chemistries of the ACQUITY UPLC column family were carefully chosen to produce the ideal combination of ultra-performance efficiencies, wide pH range and complementary selectivities. ACQUITY UPLC BEH columns and ACQUITY UPLC HSS columns are the only columns recommended for use with ACQUITY UPLC Systems.