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Waters ACQUITY Arc Multi-Dimensional Liquid Chromatography (MDLC) System

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ACQUITY™ Arc™ Multi-Dimensional Liquid Chromatography (MDLC) System 

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Multi-dimensional technology for HPLC separations

Waters ACQUITY Arc Multi-Dimensional Liquid Chromatography (MDLC) System enables scientists to achieve significant increase in sensitivity and selectivity, eliminate unwanted interferences, and characterize the most complex samples.

With the system, your lab can perform separations that are normally incompatible with a mass spectrometer by adding a second reversed-phase separation to your experiments. The system is comprised of two (2) Quaternary Solvent Managers (QSM), a Sample Manager with Flow-Through Needle (SM-FTN), and a Column Manager. Additional hardware includes, idiverter valves that are used when choosing the 30 cm Column Heater (CH) product.

  • Achieve faster set-up with less troubleshooting and more confidence with the ACQUITY Arc MDLC System’s ready-to-use configurations
  • Increase resolution by incorporating orthogonal selective columns with heart-cutting MDLC
  • Increase sensitivity and selectivity with additional reversed-phase separation

Recommended Use: For heart cutting MDLC where increased resolution is needed.

Increase resolution of an elution with heart-cutting functionality

The ACQUITY Arc MDLC System is set up to take a heart cut from the first dimension to another dimension by using a loop trap for peak refocusing, enabling scientists to achieve increased resolution of a specific elution in one dimension and use a different set of conditions on a second separation.

ACQUITY Arc Multi-Dimensional Configuration for Heart Cutting.

Purposefully designed for MDLC

The ACQUITY Arc MDLC System is specifically designed for MDLC applications. This system can easily house two columns with different column chemistries (up to 150 mm length) with independent temperature control for each column and operation as well as active solvent pre-heaters, providing versatility for orthogonal separations.

Specifications:

System Features
Total system bandspread, 4s ≤30 μL (default configuration)
Dwell volume (total system) Path 1≤1450 μL
Path 2≤1150 μL
Gradient delay volume Path 1≤1050 μL
Path 2≤750 μL
Integrated leak management Leak sensors, as standard, and safe leak handling
Quantum synchronization Injection synchronization between pump and injector enhances retention time reproducibility
Operating flow rate range 0.001 to 5.000 mL/min, in 0.001 mL increments
Maximum operating range 9500 psi up to 5.000 mL/min
pH range 1 to 12.5
Unattended operation Leak sensors and safe leak handling, full 96-hour diagnostic data display through console software
Cycle time ≤30 seconds inject-to-inject
Quaternary Solvent Manager-R
Solvent capacity Blend up to four solvents in any combination (standard); total capacity of nine solvents with integrated solvent select valve (optional)
Number of fluidic paths Three (Path 1, Path 2, and waste), with Arc Multi-flow path technology (standard)
Dwell volume selection Automated with Arc Multi-flow path technology
Solvent conditioning Integrated vacuum degassing, four chambers
Gradient formation Low-pressure mixing, quaternary gradient
Gradient profiles 11 gradient curves [including linear, step (2), concave (4), and convex (4)]
Check valves Passive check valves
Flow accuracy +/- 1.0% at 0.5, 3.0, and 5.0 mL/min
Flow precision ≤0.075% RSD or +/-0.020 min SD, whichever is greater, based on six replicates [60:40 water:methanol pre-mixed; 1.5 mL/min; alkylphenone mix; 24.0 μL injection volume; CORTECS C18 2.7 μm, 4.6 x 50 mm; 35 °C; UV @254 nm]
Composition ripple ≤0.5 mAU [mobile phase containing 0.1% TFA in water/acetonitrile; 1.5 mL/min; CORTECS C18 2.7 μm, 4.6 x 50 mm; 35 °C; UV @214 nm]
Composition accuracy +/- 0.5% absolute (full scale) from 5 to 95%; 0.5 to 5.0 mL/min [methanol; methanol with 5.0 mg/mL caffeine step gradient; UV @273 nm]
Composition precision +/- 0.15% RSD or 0.04 min SD, whichever is greater based on six replicate injections [60:40 water:methanol via Auto•Blend Technology; 0.5 mL/min; alkylphenone mix; 24.0 μL injection volume; CORTECS C18 2.7 μm, 4.6 x 50 mm; 35 °C; UV @254 nm]
Compressibility compensation Automatic and continuous
Priming Wet priming can run at flow rates up to 10 mL/min
Pump seal wash Standard
Primary wetted materials 316 L stainless-steel, PPS, fluoropolymer, UHMWPE blend, sapphire, ruby, zirconia, DLC, PEEK, and PEEK blend, titanium alloy
Sample Manager FTN-R
Injection volume range 0.1 to 50.0 μL as standard
Up to 1000.0 μL with optional extension loops
Sample capacity 768 [2x 384-well plate]; or 96 [2 mL vial holders]
Any two of the following: 48-position, 2.00 mL vial holder (total capacity of 96 vials)
96-well plate
384-well plate
48-position, 0.65 mL micro-centrifuge tube plate
24-position, 1.50 mL micro-centrifuge plate
Sample compartment temperature 4.0–40.0 °C, settable in 0.1 °C increments (optional)
Temperature accuracy +/- 0.5 °C at the sensor
Temperature stability +/- 1.0 °C at the sensor
Injection needle wash Integral, active, and programmable
Minimum sample required 3 μL residual, using total recovery 2 mL vials
Accuracy (aspiration) +/- 0.2 μL
Linearity >0.999; 0.2–50.0 μL
Precision <1.0% RSD from 0.5 to 0.9 μL
<0.5% RSD from 1.0 to 4.9 μL
<0.25% RSD from 5.0 to 1000.0 μL
Sample carryover ≤0.002% [Caffeine] under UV conditions
Advanced capabilities Auto-dilution; auto-addition; load ahead
Primary wetted materials 316 L stainless-steel, gold plated stainless-steel, polyimide, PEEK blend, DLC
Column Management (CM-A)
Column capacity CM-A: Two columns, as standard (maximum length of 150 mm with filter or guard column) can be supported with optional tubing kit, up to 4.6 mm internal diameter (I.D.)
Switching valves Two nine-port, eight-position valves; provides programmable, automatic, random-access switching, waste and bypass positions for rapid solvent changeover
Column compartment temperature 4.0 to 90.0 °C, settable in 0.1 °C increments; two independent heat/cool zones per module, up to six zones in stacked configuration
Temperature accuracy +/- 0.5 °C at the sensor
Temperature stability +/- 0.3 °C at the sensor
Solvent conditioning Active pre-heating
Column tracking eCord Technology tracks column usage and history
30 cm Column Heater (30 cm CH)
Column capacity Single column, up to 7.8 mm I.D.; up to 300 mm length with filter or guard column
Column selection Up to three with optional 3-column selection valve (8 port, 9500 psi)
Column compartment temperature 30 cm CH: 20.0 (or 5.0 °C above ambient) to 65.0 °C
Temperature accuracy +/- 0.5 °C at the sensor
Temperature stability +/- 0.3 °C at the sensor
Solvent conditioning Passive pre-heating
Instrument Control
Informatics compatibility Empower Chromatography Data System
Communications Ethernet
Event input/output Contact closure and/or TTL input/output
Environmental Specifications
Acoustic noise [total system] ≤65 dBA
Operating temperature range 4.0 to 40.0 °C
Operating humidity range 20% to 80%, non-condensing
Electrical Specifications
Power requirements 100 to 240 VAC
Line frequency 50 to 60 Hz
Power consumption QSM-R: 200 VAC
SM FTN-R: 400 VAC
30 cm CH: 50 W
CH30-A: 50 W
Physical Specifications
ACQUITY Arc System:
  • Quaternary Solvent Manager-R,
  • Sample Manager FTN-R,
  • 30-cm Column Heater
  • Mounting Bracket
 Width: 57.4 cm (22.6 in.)
Height: 57.1 cm (22.5 in.)
Depth: 62.8 cm (24.7 in.)
Weight: 59.1 kg (130.0 lbs)


  • Model: ACQUITY Arc MDLC System
  • Manufactured by: Waters

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