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Waters ACQUITY Premier System with Multi-Dimensional Technology

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ACQUITY™ Premier System with Multi-Dimensional Technology

Please contact our Sales Team for a quote.

Multi-dimensional technology for increased UPLC / UHPLC resolution when you need it

The ACQUITY Premier System with Multi-Dimensional Technology offers the lowest dispersion system for maximum peak capacity with the most reliable, highest performing solvent managers and valve compartments on the market, ensuring accuracy and precision of the entire assay. This multi-dimensional system configuration allows chemists to increase sensitivity and selectivity, eliminate unwanted interference, and characterize the most complex samples.

Additionally, the system extends the performance of MaxPeak High Performance Surfaces (HPS) Technology beyond the column, offering improvements in separation and detection of metal-sensitive analytes.

  • Achieve successful multi-dimensional UPLC and UHPLC experiments quicker and with robustness and more confidence with the help of ready-to-use configurations
  • Attain top-tier selectivity and sensitivity by using the ACQUITY Premier Systems with Multi-Dimensional Technology with proven chemistries, including the MaxPeak Premier Columns
  • Benefit from MaxPeak HPS Technology connected to the ACQUITY Premier Systems with an inert flow path

Recommended Use: To eliminate unwanted interferences and increase peak capacity and resolution for characterization of the most complex samples.

Functionality that meets all your laboratory’s needs

UPLC technology’s benefits like resolution, sensitivity, and throughput are crucial in multi-dimensional LC applications. Waters ACQUITY Premier Systems with Multi-Dimensional Technology is purpose-built to provide reproducible and consistent results in everything, from plumbing to software to valve control.

ACQUITY Premier Multi-Dimensional Systems can effectively perform functions such as trapping, heart cutting, parallel column regeneration, at-column dilution, and time de-coupled chromatography – all enhancing your ability to eliminate unwanted interferences, increase peak capacity and resolution for characterizing the most complex samples, and improve assay ruggedness and overall analysis speed.

Comprehensive (a) vs. Heart-Cutting (b)

Specifications:

Premier Binary Solvent Manager (BSM)
Number of solvents Up to four, in any combination of two: Al or A2 and B1 or B2
Solvent conditioning Five vacuum degasser, one allocated for injector purge solvent
Operating flow rate range 0.001 to 2.000 mL/min, in 0.001 mL increments (firmware v1.71 and later)
Compressibility compensation Automatic and continuous, no user intervention required
Plunger seal wash Integral, active, programmable
Gradient profiles 11 gradient curves [including linear, step (2), concave (4), and convex(4)]
Wet prime Automatic
Maximum operating pressure 15,000 psi up to 1 mL/min, 9000 psi up to 2 mL/min per pump, not more than 15,000 psi total
Composition accuracy ±0.5% absolute (full scale) from 5% to 95% of flow rates from 0.50 to 2.00 mL/min
Composition precision 0.15% RSD or ±0.01 min SD, whichever is greater, based on retention time
Flow precision 0.075% RSD or ±0.02 min SD, or 1.00 s for run times less than 1.00 min based on retention time or volumetric measures (0.5 to 2.0 mL/min)
Primary wetted materials Titanium, PPS, fluoropolymer, fluoroelastomer, UHMWPE blend, sapphire, ruby, zirconia, Nitronic 60, DLC, PEEK and PEEK blend, Inconel 600, FEP
Premier Quaternary Solvent Manager (QSM)
Solvent capacity Blend up to four solvents in any combination (standard); total capacity of nine solvents with integrated solvent select valve (optional)
Number of fluidic paths Three (Path 1, Path 2, and waste), with Arc™ Multi-flow path technology (standard)
Dwell volume selection Automated with Arc Multi-flow path technology
Solvent conditioning Integrated vacuum degassing, four chambers
Gradient formation Low-pressure mixing, quaternary gradient
Gradient profiles 11 gradient curves [including linear, step (2), concave (4), and convex (4)]
Check valves Passive check valves
Flow accuracy +/- 1.0% at 0.5, 3.0, and 5.0 mL/min
Flow precision ≤0.075% RSD or +/-0.020 min SD, whichever is greater, based on six replicates [60:40 water:methanol pre-mixed; 1.5 mL/min; alkylphenone mix; 24.0 μL injection volume; CORTECS C18 2.7 μm, 4.6 x 50 mm; 35 °C; UV @254 nm]
Composition ripple ≤0.5 mAU [mobile phase containing 0.1% TFA in water/acetonitrile; 1.5 mL/min; CORTECS C18 2.7 μm, 4.6 x 50 mm; 35 °C; UV @214 nm]
Composition accuracy +/- 0.5% absolute (full scale) from 5 to 95%; 0.5 to 5.0 mL/min [methanol; methanol with 5.0 mg/mL caffeine step gradient; UV @273 nm]
Composition precision +/- 0.15% RSD or 0.04 min SD, whichever is greater based on six replicate injections [60:40 water:methanol via Auto•Blend™ Technology; 0.5 mL/min; alkylphenone mix; 24.0 μL injection volume; CORTECS C18 2.7 μm, 4.6 x 50 mm; 35 °C; UV @254 nm]
Compressibility compensation Automatic and continuous
Priming Wet priming can run at flow rates up to 10 mL/min
Pump seal wash Standard
Primary wetted materials 316L stainless-steel, PPS, fluoropolymer, UHMWPE blend, sapphire, ruby, zirconia, DLC, PEEK and PEEK blend, titanium alloy
Premier Sample Manager-FTN (SM-FTN-H)
Injection volume range 0.1 to 10.0 μL as standard
Up to 1000.0 μL with optional extension loops
Accuracy (aspiration) ±0.2 μL (measured by fluid weight removed from vial with 10 μL injections averaged over 20 injections using standard 100 μL syringe)
Linearity† ≥999 (standard needle)
Precision† ≤0.25% RSD, 5 to 100 μL
Number of sample plates Any two of the following:
96 and 384 microtiter plates
48-position 2.00 mL vial plates
48-position 0.65 mL micro-centrifuge tube plates
24-position 1.50 mL micro-centrifuge tube plates
Maximum sample capacity 768 in two 384-well plates or 96 in 2 mL vial holders, four additional positions for dilution functions
Sample compartment temp. 4.0 to 40.0 °C, settable in 0.1 °C increment
Temperature accuracy ±0.5 °C at sensor
Temperature stability ±1.0 °C at sensor
Sample manager heat time ≤30 min ambient -40 °C
Injection needle wash Integral, active, programmable
Minimum sample required 3 μL residual, using Waters Total Recovery 2 mL vials (zero offset)
Sample carryover† ≤0.002% caffeine (UV)
≤0.002% sulphadimethoxine (MS)
Advanced sample manager capabilities Auto-dilution, auto-addition, and load-ahead
Primary wetted materials Vespel SCP, PEEK blend, DLC, and HPS
Column Management (CM-A)
Column capacity CM-A Two columns, as standard (maximum length of 150 mm with filter or guard column), or four columns (maximum length of 50 mm) can be supported with optional tubing kit, up to 4.6 mm internal diameter (I.D.)
Multidimensional valves Two six-port, two-position valves
Column compartment(s) temperature range 4.0 to 90.0 °C, settable in 0.1 °C increments
Two independent heat/cool zones per module
Column compartment(s) temperature accuracy ±0.5 °C at sensor
Column compartment(s) temperature stability ±0.3 °C at sensor
Column compartment heat time ≤15 min ambient -60 °C
Column compartment cool time ≤15 min 60–20 °C
Solvent conditioning Active pre-heating as standard
Column tracking eCord™ Technology column information management tracks and archives column usage history for one column
Instrumental Control
External communication Ethernet interfacing via RJ45 connection to host PC with BSM, or Column Manager and UPLC™ detectors and mass spectrometers
Event inputs/outputs Rear panel contact closure and/or TTL inputs/outputs
External control MassLynx™ v4.1 with OpenLynx™ Open Access, with specific SCN releases
User diagnostics Available through software on host PC; system control via console software
Unattended operation Leak sensors on supported modules, full diagnostic data captured through console software
Environmental
Acoustic noise <62 dBA
Operating temperature range 4.0 to 40.0 °C (39.2 to 104.0 °F)
Operating humidity range 20% to 80%, non-condensing
Power Requirements
Voltage 100 to 240 VAC
Frequency 50 to 60 Hz
Physical Dimensions
ACQUITY Premier Multi-Dimensional
System with:
  • FTN-H
  • one Binary Solvent Manager
  • one Quaternary Solvent Manager
  • Column Manager
  • Width: 83.8 cm (33 in.)
  • Depth: 86.4 cm (34 in.)
  • Height: 103.4 cm (40.7 in.)


  • Model: ACQUITY Premier System
  • Manufactured by: Waters

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