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Waters ACQUITY UPLC Systems with 2D LC Technology

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ACQUITY™ UPLC UPLC Systems with 2D LC Technology

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The lowest dispersion system for maximum peak capacity

Solve complex UPLC/UHPLC separation challenges with the ACQUITY UPLC Systems with 2D LC Technology, a family of systems and proven columns that offer the lowest dispersion for maximum peak capacity.

Waters 2D technology solutions for the ACQUITY UPLC M-Class System, ACQUITY UPLC I-Class PLUS, and ACQUITY UPLC H-Class PLUS are designed with the most reliable, highest performing solvent managers and valves on the market – for flexibility, accuracy, and precision of the entire assay.

  • Achieve successful 2D UPLC/UHPLC experiments faster, with less troubleshooting and more confidence with ready-to-use configurations
  • Attain best-in-class selectivity and sensitivity with the ACQUITY UPLC Systems and proven columns

Recommended Use: To increase analysis speed, improve sensitivity, selectivity, and perform accurate orthogonal separations.

Enhanced multidimensional UPLC capabilities

For chromatographers who require additional capabilities to increase their analysis speed, gain sensitivity, selectivity, and perform orthogonal separations, the ACQUITY UPLC systems are ideal. They meet all these needs by controlling multiple columns, valves, and pumps in various configurations.

The resolution, sensitivity, and throughput benefits of the UPLC technology are particularly more important in 2D LC applications. Waters 2D technology solutions for the ACQUITY UPLC M-Class System, ACQUITY UPLC I-Class PLUS, and ACQUITY UPLC H-Class PLUS Systems are purpose-built, from plumbing to software to valve control, providing reproducible, and consistent results.

A 2D-LC, three-pump configuration with QSM and BSM.

A 2D-LC, three-pump configuration with QSM and BSM.

Advanced functionality to better suit your laboratory's needs

ACQUITY UPLC Systems with 2D Technology can efficiently perform functions such as trapping, heart cutting, parallel column regeneration, at-column dilution, time de-coupled chromatography, and 2D comprehensive chromatography – all enhancing your ability to eliminate unwanted interferences, increase peak capacity, and resolution for characterizing the most complex samples, improve assay ruggedness, and increase the overall analysis speed.

Time de-coupled chromatography set in 2D mode with at-column dilution.

Time de-coupled chromatography set in 2D mode with at-column dilution.

Purposefully designed for 2D LC

The ACQUITY UPLC Column Manager is specifically designed for 2D applications, with the capability to house two columns with different chemistries with independent temperature control for each column, providing versatility for orthogonal separations. The column manager comes standardized with easy-to-access, low-volume, active solvent pre-heaters, resulting in the same efficiency run-to-run, and system-to-system, and supports two 150 mm or four 50 mm length columns.

ACQUITY UPLC Column Manager.

ACQUITY UPLC Column Manager.

Specifications

ACQUITY UPLC I-Class PLUS With 2D Technology System Features
Integrated leak management Leak sensors, as standard, and safe leak handling
System synchronization Injection synchronization between both pumps and the sample manager enhances retention time reproducibility
pH range† 1 to 12.5
Unattended operation Leak sensors, full 96-hour diagnostic data display through console software
ACQUITY UPLC I-Class PLUS Binary Solvent Managers
Number of solvents Up to four, in any combination of two: A1 or A2 and B1 or B2
Solvent storage Solvent tray accommodates up to four chromatographic solvents, one Sample Manager wash solvent, and one Binary Solvent Manager seal wash solvent
Solvent conditioning Integrated vacuum degassing, six lines with two allocated for the injector needle wash/purge solvents
Gradient formation High pressure mixing, binary gradient
Gradient profiles 11 gradient curves [including linear, step (2), concave (4), and convex (4)]
Operating flow rate range 0.001 to 2.000 mL/min, in 0.001 mL increments (firmware version 1.71 and later)
Maximum operating pressure 18,000 psi up to 1 mL/min, 12,000 psi up to 2 mL/min
Primary check valves Intelligent Intake Valves (i2 Valve)
Flow accuracy† ≤0.075% RSD or 0.01 min SD, (0.2 to 2.0 mL/min), whichever is greater using pre-mixed solvent
Composition ripple† (baseline noise) ≤1.0 mAu
Compositional precision† ≤0.15% RSD, or 0.01 min SD, whichever is greater
Compositional accuracy† ±0.5% absolute from 5% to 95%, 0.2 to 2.0 mL/min
Pressure pulsation ≤0.4% or 25 psi, whichever is greater
Compressibility compensation Automatic, no user intervention required
Priming Wet priming runs at a flow rate of 4 mL/min
Effective system delay volume <140 μL, independent of system back pressure (with 50 μL mixer installed)
Pump seal wash Equipped with a programmable active wash system to flush the rear of the high-pressure seals and the plungers
Flow ramping Automatic
Primary wetted materials 316 L stainless-steel, UHMWPE blend, MP35N, titanium alloy, gold, sapphire, ruby, zirconia, Nitronic 60, DLC, fluoropolymer, PEEK, and PEEK blend
Mixing options Standard: 50 μL
Optional: 100 μL and 380 μL
Quaternary Solvent Manager (QSM)
Number of solvents One to four, in any combination as standard.
Expanded solvent choices with optional six-port solvent select valve
Maximum operating pressure 15,000 psi up to 1.0 mL/min, 9000 psi up to 2.0 mL/min (firmware version 1.5x and earlier)
15,000 psi up to 1.0 mL/min, 7800 psi up to 2.2 mL/min (firmware version 1.6x and later)
Solvent conditioning Integrated vacuum degassing, four chambers.
One additional for the SM-FTN-I purge solvent
Solvent blending Automated, on-line pH, ionic strength, and organic modifier blending from pure solvents with Auto•Blend Plus Technology
Gradient formation Low-pressure mixing, quaternary gradient
Gradient profiles 11 gradient curves (including linear, step [2], concave [4], and convex [4])
Settable flow rate range 0.010 to 2.000 mL/min, in 0.001 mL increments (firmware version 1.5x and earlier)
0.010 to 2.200 mL/min, in 0.001 mL increments (firmware version 1.60)
0.001 to 2.200 mL/min in 0.001 mL increments (firmware version 1.65 and later)
Primary check valve Intelligent Intake Valve (i2 Valve)
Pressure pulsation† ≤1.0% or 25 psi, whichever is greater
Flow accuracy† ±1.0% at 0.5 to 2.0 mL/min using 100% A
Flow precision† ≤0.075% RSD or ±0.01 min SD, whichever is greater, based on six replicates (with i2 Valve)
Composition ripple† (baseline noise) ≤1.0 mAu
Composition accuracy† ±0.5% absolute (full scale) from 5% to 90% from 0.5 to 2.0 mL/min (with i2 Valve)
Composition precision† ≤0.15% RSD or ±0.02 min SD, whichever is greater, based on six replicate injections (with i2 Valve)
Compressibility compensation Automatic and continuous
Priming Wet priming can run at flow rates up to 4 mL/min. Programable from UPLC console software
Pump seal wash Equipped with a wash system to flush the rear of the high pressure seal and the plunger, integration, and programable
Flow ramping Range: 0.01 to 30.00 min to reach 2.0 mL/min
Default: 0.45 min to reach 2.0 mL/min
Primary wetted materials 316 L stainless-steel, PPS, fluoropolymer, fluoroelastomer, UHMWPE blend, sapphire, ruby, zirconia, Nitronic 60, DLC, PEEK, and PEEK blend, titanium alloy
Sample Manager (SM-FTN-I)
Injection volume range 0.1 to 10.0 μL as standard configuration.
Up to 1000.0 μL with optional extension loop
Accuracy ±0.2 μL, measured by fluid weight removed from vial with 10.0 μL injections averaged over 20 injections using standard 100.0 μL syringe
Linearity† ≥0.999
Precision† ≤0.25%, 5 to 50 μL
Maximum sample capacity Any two of the following:
• 96 and 384 microtiter plates
• 48 position 2.00 mL vial plates
• 48 position 0.65 mL micro-centrifuge tube plates
• 24 position 1.50 mL micro-centrifuge tube plates
Sample compartment temperature range 4.0 to 40.0 °C, settable in 0.1 °C increments; maintains 19 °C below ambient with a temperature range tolerance range between -2 and +4 °C
Temperature accuracy ±0.5 °C at sensor
Temperature stability ±1.0 °C at sensor
Sample manager heat time ≤30 min ambient-40 °C
Sample manager cool time ≤60 min ambient-4 °C
Injection needle wash Integrated, active, programmable
Minimum sample required 3 μL residual, using Waters’ Total Recovery 2 mL Vials (zero offset)
Sample carryover ≤0.001% caffeine (UV)
≤0.001% sulphadimethoxine (MS)
Advanced sample manager capabilities Auto-dilution and auto-addition
Primary wetted materials 316 L stainless-steel, polyimide, PEEK blend, DLC, PPS
Column Management (CM-A)
Column capacity CM-A: Two columns, as standard (maximum length of 150 mm with filter or guard column) or four columns (maximum length of 50 mm) can be supported with optional tubing kit, up to 4.6 mm internal diameter (I.D.)
Multidimensional valves Two six-port, two-position valves (CM-A only)
Column compartment(s) 4.0 to 90.0 °C, settable in 0.1 °C increments
Temperature range Two independent heat/cool zones per module
Column compartment(s) temperature accuracy
±0.5 °C at sensor Column compartment(s)
temperature stability ±0.3 °C at sensor
Column compartment heat time ≤15 min ambient-60 °C
Column compartment cool time ≤15 min 60–20 °C
Solvent conditioning Active pre-heating as standard
Column tracking eCord Technology column information management tracks and archives column usage history for one column
Sample Organizer
Sample plate capacity Sample plate capacity is configured based on the types and combinations of plates being used:
• Maximum of 19 standard microtiter plates, up to 15.5 mm high, or
• Maximum of 9 intermediate height plates (or 2 mL vial holders), up to 40.0 mm high, or
• Maximum of 6 deep well plates (or 4 mL vial holders), up to 47.0 mm high
Maximum sample capacity Maximum of 7296 samples in nineteen 384-well plates
Sample compartment temperature range 4.0 to 40.0 °C, settable in 0.1 °C increments with a tolerance range between -2.0 to +4.0
Temperature accuracy ±1 °C at the sensor
Temperature stability ±1 °C at the sensor
Instrumental Control
External communication Ethernet interfacing via RJ45 connection to host PC with BSM, or Column Manager and ACQUITY UPLC Detectors and mass spectrometers
Event inputs/outputs Rear panel contact closure and/or TTL inputs/outputs
External control MassLynx version 4.1 with OpenLynx Open Access, with specific SCN releases
User diagnostics Available through software on host PC; system control via console software
Unattended operation Leak sensors on supported modules, full diagnostic data captured through console software
Connections INSIGHT Provides real-time monitoring, automatic notification of instrument performance, and diagnostic information allowing for quicker problem resolution
Environmental
Acoustic noise <65 dB
Operating temperature range 4.0 to 40.0 °C (39.2 to 104.0 °F)
Operating humidity range 20% to 50%, non-condensing
Power Requirements
Voltage range 100 to 240 VAC
Frequency 50 to 60 Hz
Physical Dimensions

ACQUITY UPLC I-Class PLUS System
with 2D Technology comprised of:

ACQUITY UPLC Sample Manager - FTN-I,
two Solvent Managers, and Column Manager
  • Width: 83.8 cm (33 in.)
  • Height: 103.4 cm (40.7 in.)
  • Depth: 86.4 cm (34 in.)
Note: dimensions are listed with only components listed above.

Ordering Information

Part Title Part Number
ACQUITY UPLC I-Class PLUS System with 2D Technology (SM-FTN-I), 2x BSM 176015130
ACQUITY UPLC I-Class PLUS System with 2D Technology (SM-FTN-I), QSM/BSM 176015131


  • Model: ACQUITY UPLC Systems with 2D LC
  • Manufactured by: Waters

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