Chromolith DIOL HPLC Column, 4.6 x 25 mm - 153170

Merck Chromolith DIOL HPLC Column, 4.6 mm I.D. x 25 mm Length

Product Number: 153170

Analytics and Sample Preparation > Chromolith® DIOL 25-4.6 HPLC column

Chromolith® Diol columns are more versatile than bare silica columns, and often offer improved reproducibility. The bonded phase’s hydroxyl groups provide good selectivity without excessive retention. This is due to weaker hydrogen bonding with diol groups than with silanols on a bare silica surface. In aqueous phases, the diol phase can effectively shield the silica surface from interacting with proteins. Diol columns are commonly used for the separation of steroids and sterols under normal-phase conditions. Chromolith® Diol columns are suitable for the separation of alcohols, amino acids, carotinoids, oils, glycols, preservatives, proteins, sugars, sulfonamides, and water-soluble vitamins.

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