Coated phases. The traditional coated chiral stationary phases (CSPs) from CHIRAL TECHNOLOGIES are available in 3-µm particle size and offer superior speed and column resolving power. These columns packed with 3-µm CSPs offer high-speed separations, reduction in analysis time, more samples per day and a reduction in cost per sample. Columns, packed with 3-µm particles, may be used in conventional HPLC units without significant loss in performance, even with the smaller column dimensions.

The original Daicel CSPs were formed by coating the chiral polymer from the derivatization of the amylose and cellulose on 10-µm diameter silica. Subsequently, CHIRALPAK AD, CHIRALPAK AS, CHIRALCEL OD, CHIRALCEL OJ, CHIRALCEL OB, and CHIRALCEL OC were superseded by products made with higher-efficiency 5-µm particles. These CSPs are designated AD-H, AS-H, OD-H, OJ-H, OB-H and OC-H. Because these CSPs are made by coating the polymer on the silica, any solvent that will dissolve the polymer will remove the coating and damage the CSP. For this reason there are strict limits on the mobile phases that may be used and one of Daicel's priorities is to develop further the range of immobilized CSPs to eliminate these restrictions.