CHIRALPAK® & CHIRALCEL®

Cellulose tris(4-chloro-3-methylphenylcarbamate)

Coated phases. The traditional coated chiral stationary phases (CSPs) from CHIRAL TECHNOLOGIES are available in 3-µm particle size and offer superior speed and column resolving power. These columns packed with 3-µm CSPs offer high-speed separations, reduction in analysis time, more samples per day and a reduction in cost per sample. Columns, packed with 3-µm particles, may be used in conventional HPLC units without significant loss in performance, even with the smaller column dimensions.

The original Daicel CSPs were formed by coating the chiral polymer from the derivatization of the amylose and cellulose on 10-µm diameter silica. Subsequently, CHIRALPAK AD, CHIRALPAK AS, CHIRALCEL OD, CHIRALCEL OJ, CHIRALCEL OB, and CHIRALCEL OC were superseded by products made with higher-efficiency 5-µm particles. These CSPs are designated AD-H, AS-H, OD-H, OJ-H, OB-H and OC-H. Because these CSPs are made by coating the polymer on the silica, any solvent that will dissolve the polymer will remove the coating and damage the CSP. For this reason there are strict limits on the mobile phases that may be used and one of Daicel's priorities is to develop further the range of immobilized CSPs to eliminate these restrictions.

The predecessors to the immobilised columns, traditional CHIRALPAK® and CHIRALCEL® DAICEL coated polysaccharide Chiral Stationary Phases are made with a spherical high quality silica support onto which the polymeric chiral selector (amylose or cellulose derivatives) is physically coated. Due to the coated nature of these chiral supports, solvents should be carefully selected.

CHIRALPAK® AY-H, AZ-H & CHIRALCEL® OZ-H HPLC & SFC columns are phases that have been produced for several years by DAICEL. As the selectors are significantly different from existing DAICEL phases they allow new separations to be developed. These phases are now available as packed HPLC and SFC analytical and semi preparative columns. They are effective in developing new compound specific separations. They are an excellent complement in terms of recognition behaviour to the primary screen systems/sets of CHIRALPAK® IA, IB & IC or the alternative CHIRALPAK® AD, AS & CHIRALCEL® OD, OJ.

These columns are coated onto the silica support and hence can only be used with mobile phases of alkane/alcohol, acetonitrile/alcohol or mixed alcohol systems.

• New recognition profiles that allow new separations
• Complementary to existing DAICEL screening methodologies
• Excellent columns efficiency
• Easy use of the column