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GL Sciences Bio LC Columns ProteoSil / MonoSelect, Bioseparation Solution Information Page

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Bio LC Column

Bioseparation Solution - ProteoSil / MonoSelect

  • Peptide Mapping
  • Nucleic acids / oligonucleotides
  • Monoclonal Antibodies

GL Sciences Bio LC Columns are HPLC solutions specifically designed for bio molecules proteomics such as protein, peptide and nucleic acid specifies. All columns are available with bio-inert PEEK and stainless steel hardware.
Packing materials are made of high-purity silica with pore sizes of 100Å, 200Å, and 300Å, and are available in reversed phase, HILIC, and size exclusion columns. Low lot-to-lot variation and consistent quality also make it ideal for LC/MS applications.

Product Line

ProteoSil 300-C18Designed for advanced protein analysis, the ProteoSil 300-C18 column offers the ideal capabilities when enhanced retention and sample load are critical for C4 or C8 columns.
ProteoSil 200-C18Ideal for mid-sized molecules, the ProteoSil 200-C18 column allows for separation across 100Å pore columns and is easy to clean for faster analysis.
ProteSil 100-C18Offering high inertness and durability, the ProteoSil 100-C18 is perfect for analyzing low-molecular-weight compounds, enhancing sensitivity in LC-MS applications.
ProteoSil 300-C4Tailored for the analysis of proteins and peptides, especially hydrophobic peptides, the ProteoSil 300-C4 facilitates shorter retention times and is ideal for proteins with moderate retention needs.
ProteoSil 300-SECEquipped with dihydroxypropyl groups bonded to silica gel, the ProteoSil 300-SEC column is suited for the analysis of large molecules and can be used as a dial column.
MonoSelect RP-mAbFeaturing a silica monolith structure with phenyl groups, the MonoSelect RP-mAb column is optimized for monoclonal antibodies analysis and high-sensitivity LC/MS applications.
ProteoSil 300-C8Optimized for proteins and peptides, the ProteoSil 300-C8 ensures unique selectivity and hydrophobicity compared to shorter-chain C4 phases, suitable for protein and hydrophobic peptide separations.
ProteoSil 200-C8Specialized for the analysis of mid-sized molecules, the ProteoSil 200-C8 shows superior retention for analytes that are strongly retained by C18 columns.
ProteoSil 100-C8Suitable for low-molecular-weight peptides, the ProteoSil 100- C8 provides high inertness an
ProteoSil HILICModified with amide groups, the ProteoSil HILIC column excels in the separation of highly hydrophilic compounds, peptides, glycans, and oligonucleotides.
ProteoSil 100-SECConstructed for aqueous size-exclusion chromatography, the ProteoSil 100-SEC can handle higher operating pressures and is suitable for series column configurations.
MonoSelect nPECDesigned for rapid separation of nanoparticles and free lowmolecular- weight compounds, the MonoSelect nPEC column is crucial for assessing drug encapsulation rates in liposome formulations.

 

ModeTargetMWColumnPhaseParticle sizePore size
(Å)
Reversed PhaseProteins / Peptides
Oligonucleotides / Nucleic Acids		>20,000ProteoSil 300-C18C185300
ProteoSil 300-C8C85300
5,000-20,000ProteoSil 200-C18C181.9, 3, 5200
<5,000ProteoSil 100-C18C181.9, 3, 5100
Proteins / Peptides
Monoclonal Antibodies
Oligonucleotides / Nucleic Acids		>20,000ProteoSil 300-C4C45300
Proteins, Monoclonal Antibodies
Antibody-Drug Conjugate(ADC)
Sub unit		>100,000MonoSelect RP-mAbPhenylMonolith600
HILICProteins / Peptides
Monoclonal Antibodies		-ProteoSil HILICAmide1.9, 3, 5100
SECProteins / Peptides
Monoclonal Antibodies
Oligonucleotides / Nucleic Acids		5,000-600,000ProteoSil 300-SECDIOL5300
SEC + RPLNP, Exosome MonoSelect nPECHydrophilic
Polymer		Monolith110

  • Model: ProteoSil Info
  • Manufactured by: GL Sciences

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