Waters ACQUITY Arc HPLC and UHPLC System

ACQUITY Arc HPLC and UHPLC System

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HPLC and UHPLC method compatibility at the flip of a switch

Bridge the gap between HPLC and UHPLC applications while continuing to support validated assays with the ACQUITY Arc...

The ACQUITY Arc System is a quaternary-based, modern LC system for scientists working with established methods who are looking for the versatility and robustness required to bridge the gap between HPLC and UHPLC while continuing to support validated assays.

• Achieve both HPLC and UHPLC separations in one instrument with regulatory compliant-ready hardware and software 
• Boost the chromatographic performance of your methods with the benefits of 2.x μm particle columns 
• Eliminate the cumbersome and error-prone approach of manual preparation with on-demand mobile phase creation with Auto?Blend Plus Technology
• Adjust for differences in dwell volume between systems to achieve repeatability between systems with the combination of the dual-flow paths and Gradient SmartStart

Overview

• Go from HPLC to UHPLC with the flip of a switch - Easily switch between HPLC and UHPLC operation with multi-flow technology to select the dwell volume that fits best the column separation.
• Simplify your daily set-up - Fully automate your daily system start-up, including system priming and equilibration, with Empower 3 Software. Get real-time information on all of system components in one location, with a simple and intuitive interface using the ACQUITY Console.
• Speed mobile phase preparation with more repeatability - Reduce the time it takes to prepare mobile phases while improving the day-to-day repeatability of your preparations by preparing your pH buffers online from pure solvents with AutoBlend Plus Technology. 
• Minimize carryover - Achieve ultra-low carryover (≤0.002%) by continuously cleansing the needle during the run with an advanced flow-through-needle design. 
• Achieve flexibility and stability for method development - Column manager options available for up to 15 columns ranging in length from 50 mm to 300 mm with a temperature range of 4 °C to 90 °C. Optional and integrated column selection valve provide fast, unattended column changeover. 
• Provide stability for method transfer needs - Provide stable, uniform temperature management with integrated active pre-heating options to ensure method repeatability from lab to lab. Gradient SmartStart easily adjusts for system volume differences when transferring methods from an alternative LC system without alteration to the method table. 

Recommended Use: For modernizing your chromatography while being able to run legacy, validated methods.

Replicate your established methods

Get seamless and efficient transfer, adjustment, or improvement of methods from any LC platform without compromise in method integrity or changes to validated gradient tables with the ACQUITY Arc System. 

The ACQUITY Arc System can replicate your established HPLC methods by compensating for these differences with unique features such as the Arc multi-flow path technology and Gradient SmartStart. With these innovative attributes, you can seamlessly replicate your existing chromatographic results to meet your acceptance criteria without changes to validated gradient tables.

Seamless transfer of an impurity method from an alternative HPLC vendor to the ACQUITY Arc System.

Go from HPLC to UHPLC with the flip of a switch

With the multi-flow path technology in the ACQUITY Arc System, you can easily switch between HPLC and UHPLC operation by selecting the dwell volume that best fits the column separation. The ACQUITY Arc System’s reliability and robustness ensures product consistency and compliance with regulatory guidelines, all while minimizing downtime and inefficiencies.

With the ACQUITY Arc System, you can maximize productivity by combining system dispersion characteristics with efficient and rapid 2.x µm UHPLC separations or larger, 3.0–5.0 µm particles - so you get the flexibility your lab needs to support a wide-range of LC applications.

Comparison of the HPLC method and UHPLC method results on the ACQUITY Arc System. Elution order: thymine, caffeine, coumarin, prednisone, and flavone.

Simplify your daily set-up

Improve your laboratory workflow with the advanced software capabilities included with the ACQUITY Arc System.

• Fully automate your daily system start-up, including system priming and equilibration, with Empower 3 Software.
• Get real-time information on all of system components in one location with a simple and intuitive interface using ACQUITY Console.
• Prepare your pH buffers online from pure solvents, significantly reducing the time it takes to prepare mobile phases while improving the day-to-day repeatability of your preparations with Auto Blend Plus technology.

Effect of pH on charge variant analysis of trastuzumab. Auto•Blend Plus was used to manipulate small changes in pH, while programming a salt gradient from 25–125 mM NaCl over 10 minutes, while holding the indicated pH constant over the length of the run.

Develop methods that stand the test of time

Need an orthogonal detection approach to UV in your method development? Streamline your method development with an LC-MS solution that’s as easy to use as photodiode array detection.

The ACQUITY Arc System is fully compatible with the ACQUITY QDa Mass Detector, supporting efficient and robust method development by expanding the information you can get from your system using the same Empower Software. The system automatically pairs qualitative mass spectral data to the peaks in your chromatogram, leaving nothing to chance.

• Confirm the identity of peaks in a separation without injecting standards

• Identify new peaks in a separation with molecular weight information

• Detect unresolved peaks and determine if a peak is homogenously pure

• Easily track peaks as method conditions are changed

Automatically pair qualitative mass spectral data to peaks in your chromatogram. This data shows the method transfer of a USP assay for fluconazole using the ACQUITY Arc System. Here the peak has same m/z of a related compound. 1. Related compound A; 2. Related compound B; 3. Related compound C; 4. fluconazole.

Specifications