Distek Apparatus 6 Rotating Cylinder, 2 inch - 6-3200-0144

Distek Apparatus 6 Rotating Cylinder, 2 inch 

Product Number: 3200-0144

Apparatus 6 Rotating Cylinder, 2 Inch, Uses Extension Adapter p/n 3200-0144. Serialized.

The human skin has offered several potential advantages for the systemic delivery of drugs. Because the drug reached the blood circulation directly it does not have to travel through the gastrointestinal tract, where it can degrade, suffer from poor absorption which may cause distress, or become partially metabolized by the liver before reaching systemic circulation. Transdermal products have evolved to accomplish these and other needs but have been a challenge in terms of performance testing. Several modifications to existing USP dissolution apparatus have been developed and adopted into the USP as official apparatus. This module will specifically cover USP Apparatus 6, the rotating cylinder which has specific advantages over the paddle over disk methods and reciprocating holder apparatus. The rotating cylinder apparatus is designed to handle much larger patches, while holding the patch to the cylinder wall during the test. This talk will explore the advantages as well as cover the practical use of the apparatus.