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Nacalai Tesque COSMOSIL 5C22-AR-II Analytical HPLC Column, 5 µm, 120 Å, 4.6 x 150 mm, 1/Pk - 04598-51

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Cosmosil® C22-AR-II

Nacalai Tesque COSMOSIL 5C22-AR-II Analytical HPLC Column, 5µm, 120Å, 4.6mm I.D. x 150mm Length, 1/Pk

Product Number: 04598-51

Alkyl chain columns - Docosyl group - Polymeric

COSMOSIL alkyl type columns are columns that bond C22 (docosyl group), C8 (octyl group), C4 (butyl group), and TMS (triethyl group) to the packing material. The retention order of samples on the column according to the lipophilic effect is C22=C18>C8>C4>TMS. Columns with lipophilic effect lower than C18 or C22 are effective in separating highly lipophilic compounds or compounds with lipophilic structures that are very different from each other. The lipophilicity of C22 is the same as that of C18. However, the stereoselectivity of C22 is higher than that of C18.

Reversed Phase HPLC Columns:

 PFPCN-MSC22-AR-IIC8-MS
Silica GelHigh purity porous spherical silica
Average Particle Size5 µm
Average Pore Sizeapprox. 120 Å
Specific Surface Areaapprox. 300 m2/g
Bonded PhasePentafluorophenyl Cyanopropyl groupDococyl groupOctyl group
Bonding TypeMonomericPolymericMonomeric
Main InteractionHydrophobic
interaction
Dipole-dipole
Hydrophobic interaction
End-capping TreatmentNear-perfect Treatment
Carbon Loadapprox. 10%approx. 7%approx. 19%approx. 10%
pH Range2-7.5
 C4-MSTMS-MSPE-MS
Silica GelHigh purity porous spherical silica
Average Particle Size5 µm
Average Pore Sizeapprox. 120 Å
Specific Surface Areaapprox. 300 m2/g
Bonded PhaseButyl groupTrimethyl groupPhenylethyl group
Bonding TypeMonomeric
Main InteractionHydrophobic interactionHydrophobic
interaction
Dipole-dipole
End-capping TreatmentNear-perfect Treatment
Carbon Loadapprox. 7%approx. 5%approx. 10%
pH Range2-7.5

Column Specifications:

Product DescriptionCOSMOSIL 5C22-AR-II Packed Column (4.6 mm I.D. x 150 mm)
Quantity1 pcs
ManufacturerNacalai Tesque
Product TypeHPLC Column
Length150 mm
Internal Diameter4.6 mm
Particle Size5 µm
Average Pore Size120 Å
Bonding PhaseDococyl
Bonding typePolymeric
Chemistry Producers TermC22-AR-II (5C22-AR-II)
Carbon Loadapprox. 19%
Bet Surface Area [m2/g]300.0
EndcappingEnd-Fitting: Waters type
End capping treatmentNear-perfect treatment
USP code-
Specific surface areaapprox. 300m2/g
Hardware MaterialStainless Steel
Hardware TypeAnalytical Column
pH Minimum2.0
pH Maximum7.5
Mode of SeparationReversed Phase Chromatography (RP)
TechnologyHigh-Performance Liquid Chromatography (HPLC)
MatrixSilica
Particle Morphologyspherical, fully porous

Additional Column Sizes are available - Please contact our Sales Team with your requirements.

Cosmosil Columns Online Catalogue:


  • Model: 04598-51
  • Manufactured by: Nacalai Tesque

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