COSMOSIL 5PBr 5 µm HPLC Columns

Separation of hydrophilic compounds in reversed-phase conditions

Hydrophilic interaction chromatography (HILIC) is an increasingly popular analytical technique. However, it is often difficult to develop a robust method due to users’ less familiarity with HILIC conditions. Furthermore, high concentration of acetonitrile used in HILIC mobile phase makes it extremely sensitive to samples’ water concentration; injecting samples in high water concentration often results in poor peak shapes. COSMOSIL PBr enables separation of hydrophilic compounds in reversed phase conditions, maintaining sharp peak shapes even with aqueous samples.

• Separate hydrophilic compounds in reversed-phase conditions
• Simple mobile phase condition compared to HILIC
• More sample loading capacity than HILIC
• Alternative selectivity to C18 column