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COSMOSIL Reversed Phase Speciality Columns

Reversed phase HPLC columns have been widely used because of their superior resolution, high theoretical plate number and ease of use. Since hydrophobic interaction is the dominant separation mechanism in reversed phase chromatography, conventional stationary phases such as C18 and C18 do not offer optimum selectivity for compounds with similar hydrophobicity. COSMOSIL offers a broad selection of columns with unique stationary phases for separation of these difficult analytes. These columns offer improved separation of structurally similar compounds that are difficult to analyze with a C18 type column.

Specifications:

Packing MaterialCholesterPBrπNAPPYENPE
USP CodeL101 
Silica GelHigh Purity Porous Spherical Silica 
Particle Size5 µm
Pore Sizeapprox. 120Å
Specific Surface Areaapprox. 300 m2/g
Stationary PhaseCholesteryl GroupPentabromobenzyl groupNaphthylethyl
Group		Pyrenylethyl
Group		Nitrophenylethyl
Group
Bonding TypeMonomeric
Main Interaction

Hydrophobic Interaction

Hydrophobic interactionHydrophobic InteractionHydrophobic InteractionHydrophobic Interaction
Molecular Shape SelectivityDispersion forceπ-π Interactionπ-π Interactionπ-π Interaction
---Dispersion ForceDipole-dipole Interaction
---Charge-transfer Interaction-
End Capping TreatmentNear-perfect treatment
Carbon Contentapprox. 20%approx. 8%approx. 11%approx. 18%approx. 9%
pH Range2–7.5
FeatureUsable under the same conditions as C18Separate hydrophilic compounds in reversed phase conditionsStronger π-π interaction than phenyl columnStrongest π-π interactionDipole-dipole interaction
High molecular shape selectivity

 

COSMOSIL PBr Columns
COSMOSIL PBr Columns
COSMOSIL Cholester Columns
COSMOSIL Cholester Columns
COSMOSIL nNap Columns
COSMOSIL nNap Columns

COSMOSIL PBB-R HPLC Columns
COSMOSIL PBB-R HPLC Columns
COSMOSIL NPE HPLC Columns
COSMOSIL NPE HPLC Columns
COSMOSIL PYE HPLC Columns
COSMOSIL PYE HPLC Columns

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