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Purospher® RP-18 Endcapped 4-4 LiChroCART® HPLC Guard Columns 10/Pkg, 90 Å, 5 μm, 4 x 4 mm - 150167

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Purospher® RP-18 Endcapped

Inner Diameter (I.D.): 4 mm
Length: 4 mm
Package Contents: 10 Pieces


Purospher® RP-18 endcapped is a versatile HPLC column providing separations with excellent peak symmetry for both 
basic and strongly acidic compounds. Simply composed eluents can be employed for the separation of basic drugs. 
This results in shorter analysis time and increases laboratory productivity. The excellent balance of chromatographic 
properties is the key for better separating complex samples with simple, neutral eluents. Purospher® RP-18 endcapped 
is based upon a high purity, metal-free silica with a complete coverage of the silica surface with C18-ligands. This 
enables a peak-tailing free elution of acidic, basic, and chelating compounds. Key applications are the determination
of various azo dyestuff amines and beta-blockers demonstrating the good resolution and high peak symmetry.

Additionally, the chemical stability of Purospher® RP-18 endcapped is high. Mobile phase conditions at pH 8 could be 
applied for a long period of time without loss of performance. Purospher® RP-18 endcapped columns have excellent 
selectivity and column efficiency – allowing robust method development in R&D and QC.

Purospher® RP-18 endcapped benefits
  • Excellent column selectivity for both basic and strongly acidic drugs
  • Robust and fast method development with simple, neutral eluents
With LiChroCART® cartridges the user works with re-usable endfittings which fit different cartridge lengths. 
the cartridges may be changed within the shortest possible time. Changing a separation cartridge from a length 
of 125 to 250 mm and back presents no problems. Furthermore, the adaptation of internal diameter (3 mm or 2 mm) 
to the analysis problem is possible within a few minutes. The endfittings are designed to allow the cartridges to be 
hand-sealed at normal working pressures of 150 to 200 bar without the need for any tools. Only at higher pressures 
may further tightening with a wrench become necessary.


Specifications of Purospher® RP-18 endcapped

Sorbent characteristics: High-purity silica particles C18 with special modification and deactivation of the surface
Metal content: Na, Ca, Mg, Al: 1 ppm; Fe: 3 ppm
Particle shape: spherical
Particle size: 5 μm
Pore size: 9 nm (90 Å)
Pore volume: 1.05 mL/g
Specific surface area: 480 m2/g
Carbon load: 18.0% C
Coverage of the surface: 4.1 μmol/m2
Efficiency: 80,000 N/m
pH range: pH 2 - 8
Shipping eluent: Acetonitrile/Water


  • Model: 1.50167.0001
  • Manufactured by: Merck Chemicals

Product 16/101

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