Waters BioResolve Premier RP mAb Polyphenyl Column, 450 Å, 2.7 µm, 2.1 mm x 20 mm, 1/pk - 186011019

Waters BioResolve Premier RP mAb Polyphenyl Column, 450 Å, 2.7 µm, 2.1 mm x 20 mm, 1/pk

Part Number: 186011019

BioResolve Premier RP mAb Polyphenyl Column contains 2.7 μm superficially-porous-silica particles having an average pore diameter of 450Å. The particles are functionalized with a proprietary polyphenyl bonding process that was specifically designed for LC or LC-MS analyses of intact IgG monoclonal antibodies and their fragments. The column hardware utilizes the MaxPeak High Performance Surface (HPS) that reduces unwanted analyte surface interactions and greatly improves peak shape, recovery, and reproducibility. Suggested use: High throughput Reversed-phase (RP) chromatography

BioResolve RP mAb Polyphenyl Columns

• Improved peak capacity for better component resolution
• Minimal injection-to-injection carryover for increased confidence of analyses
• Ability to operate at lower temperatures for less on-column sample degradation
• Ensured column-to-column performance by being quality control (QC) tested with a NIST-based, mAb subunit standard
• LC system (HPLC, UHPLC, UPLC) agnostic, doesn’t compromise required separation performance
  VanGuard FIT column option

BioResolve Columns

Innovative solutions for mAb characterizations

Biological separation challenges are becoming more complex each day. BioResolve chemistry consumables provide innovative solutions for specific analytical challenges related to mAb-based and associated biotherapeutic drugs.

Waters BioResolve Columns include column chemistries that can be used on UPLC, UHPLC, and HPLC platforms with a relevant application-specific standard and superior out-of-the-box performance.

• Achieve batch and column consistency for mAb separations
• Reversed-phase solutions for intact and IdeS digested mAbs
• Meet analysis requirements with a strong cation-exchange-based offering for mAb charge variant analyses and high pore volume, 200 Å SEC offering for mAb aggregates, monomers, and fragments analyses
• Increase confidence in your data with flexible, reproducible, high resolution separations
• Increased lifetime without sacrificing performance with BioResolve Guards
• Minimize band spread and enhance mAb separations with Cation-Exchange column technology
• Confirm column, system, and separation method performance with NIST-based Intact mAb standard, mAb Size
• Variant standard, and mAb Charge Variant standard
• Implement charge variant profiling easily with BioResolve CX pH buffer concentrates and IonHance CX-MS buffers for on-line IEX-MS analysis
• Recommended Use: For improved speed, sensitivity, and resolution in methods development.

Specifications: