Waters BioResolve Premier SCX mAb Column, 3 µm, 2.1 mm x 20 mm, 1/pk - 186011020

Waters BioResolve Premier SCX mAb Column, 3 µm, 2.1 mm x 20 mm, 1/pk

Part Number: 186011020

BioResolve Premier SCX mAb Column, 3 μm, corrosion–resistant columns which contain non-porous, polymer-based particles grafted with a rigorously-optimized, multi-component network of negatively charged sulfonic acid ligands. This innovative column technology, delivers reproducible, high-resolution, charged-based separations of mAbs and other proteins in both LC and LC-MS applications using robust salt or pH gradient methods. The column hardware utilizes the MaxPeak High Performance Surface (HPS) that reduces unwanted analyte surface interactions and greatly improves peak shape, recovery, and reproducibility.

BioResolve SCX mAb Columns

• Ability to reliably separate, with accurate charge variant quantitation, a wide range of mAbs using optical or LC-MS compatible mobile phases
• Excellent batch-to-batch and column-to-column performance consistency
• LC system (HPLC, UHPLC, UPLC) agnostic, doesn’t compromise required separation performance
• Ensured column-to-column performance by being QC tested with a NIST-based, mAb Charge Variant standard
• VanGuard FIT column option

BioResolve Columns

Innovative solutions for mAb characterizations

Biological separation challenges are becoming more complex each day. BioResolve chemistry consumables provide innovative solutions for specific analytical challenges related to mAb-based and associated biotherapeutic drugs.

Waters BioResolve Columns include column chemistries that can be used on UPLC, UHPLC, and HPLC platforms with a relevant application-specific standard and superior out-of-the-box performance.

• Achieve batch and column consistency for mAb separations
• Reversed-phase solutions for intact and IdeS digested mAbs
• Meet analysis requirements with a strong cation-exchange-based offering for mAb charge variant analyses and high pore volume, 200 Å SEC offering for mAb aggregates, monomers, and fragments analyses
• Increase confidence in your data with flexible, reproducible, high resolution separations
• Increased lifetime without sacrificing performance with BioResolve Guards
• Minimize band spread and enhance mAb separations with Cation-Exchange column technology
• Confirm column, system, and separation method performance with NIST-based Intact mAb standard, mAb Size
• Variant standard, and mAb Charge Variant standard
• Implement charge variant profiling easily with BioResolve CX pH buffer concentrates and IonHance CX-MS buffers for on-line IEX-MS analysis
• Recommended Use: For improved speed, sensitivity, and resolution in methods development.

Specifications: