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Waters ACQUITY QDa Mass Detector

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ACQUITY QDa Mass Detector

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Press On to Bring the Power of Mass Detection to Your Lab

With great detection power comes great possibility – Minimize the risk of unexpected coelutions or components and confirm trace components with the analytical confidence of mass detection. Enhance the analytical value and productivity of each analysis.Simply power on, and you’re ready to go. Zero user set-up optimization, calibration, or adjustment. Run your analyses?it just works. When you’re done, just power-off

  • Intuitive operation
  • More information from every sample
  • Effortless integration
  • Increased efficiency
  • Resolving complexity

Intuitive Operation

ACQUITY QDa is as intuitive as an optical detector, with the robustness to handle all of your analyses. Working in harmony with your chromatography, it is pre-optimized to work with your samples, without the sample-specific or user adjustments typical of traditional mass spectrometers. For the first time, any analytical scientist can consistently generate the highest quality mass spectral data, routinely without the need for any special training or expertise thus eliminating any need to contract out and wait for results from specialist analytical service laboratories.

More information from every sample

With ACQUITY QDa Detector, you can minimize the risk of unexpected coelutions or components and you can confirm trace components with certainty because of the analytical confidence that mass detection brings. Enhance the analytical value and productivity of each analysis, eliminating the need to run all the additional assays or time-consuming alternative techniques.

Working in synergy with optical detection, you can significantly reduce the chance that a sample component will go undetected.

Confirm identities, track components, highlight coelutions, quantify low levels & detect compounds not accessible  by UV.

Effortless integration

The ACQUITY QDa Detector is compatible with all Waters ACQUITY UPLC, ACQUITY UPC2, Alliance HPLC, and purification LC and SFC systems. The ACQUITY QDa Mass Detector is complementary to your current Waters optical detectors including ACQUITY UPLC PDA, TUV, or FLR, or ACQUITY UPC2 PDA optical detectors.

The mass spectrComplete characterization of your separation - all in one workflowal information combines seamlessly into the same workflow, routinely giving you more complete characterization of your separation.

Process, interpret, visualize, and compare the most complex data, and turn it into meaningful information quickly and simply. The ACQUITY QDa Detector is fully compatible with Empower Software, our industry-leading chromatography data software platform.

With integrated optical and mass detector data processing workflows, you can also interrogate mass spectral data in the same way and same workflow as you do PDA data. The ACQUITY QDa Detector is also fully compatible with MassLynx Software and its suite of Application Managers.

Resolving complexity

Whether your focus is on advancing healthcare, protecting the environment, safeguarding our food and water supplies, or making new materials, the ACQUITY QDa Detector dramatically improves the capability of your existing analytical or purification system and is your simplest route to reliable, versatile mass detection.

Specifications:

SYSTEM HARDWARE SPECIFICATIONS
API Source and ionization modes Adjustment-free high performance ZSpray™ dual-orthogonal atmospheric pressure
ionization (API) electrospray (ES) interface for robustness and reliability
Ion polarity switching for comprehensive compound coverage
Integrated adjustment-free plug and play probe for reduced dispersion and reliability De-clustering cone gas
Disposable sample aperture for minimized maintenance and repeatability Tool free access to customer serviceable elements
Automated control of gas flows and heating elements
Ion source transfer optics Dual off-axis ion guides for elimination of neutral noise with increased sensitivity and
robustness. Includes high efficiency conjoined stacked ring ion guide and second stage quadrupole ion guide
Mass analyzer Automated mass calibration and resolution verification for constant data quality. Single high resolution quadrupole analyzer, plus pre-filter to maximize resolution and transmission while preventing contamination of the mass analyzer
Detector Low noise, off axis, long life photomultiplier detector Digital dynamic range up to 4 x 106
Dimensions Width: 35.3 cm (13.9 in.)
Height: 20.0 cm (7.9 in.)
Depth: 65.0 cm (25.6 in.) or 75.0 cm (29.5 in.) including integrated diaphragm backing pump
Weight: 26.4 kg (58 lbs) or 29.4 kg (65 lbs) including integrated diaphragm backing pump
Power supply 110-240 V ac 50/60 Hz
Regulatory approvals/marks CE, CB, NRTL (CAN/US), RCM
SYSTEM SOFTWARE SPECIFICATIONS
Software Systems supported on Empower® 2 and 3 and MassLynx® 4.1
Automated mass calibration, mass resolution control and mass calibration, and resolution verification
Automated diagnostics, checks, and alerts
Automated full scan MS acquisition Automatically-optimized for enhanced data quality at required data rate as MS spectra per second (Hz), simplifying full scan MS acquisition
Automated SIR acquisition Automatically-optimized for enhanced data quality at required data rate as MS data points
per second (Hz), simplifying SIR acquisition. Automated scheduling of SIR acquisition windows for optimized data quality
PERFORMANCE SPECIFICATIONS
Acquisition modes Full scan MS
Selected Ion Recording (SIR)
RADAR™ An information-rich acquisition approach that allows you to collect highly specific quantitative data for target compounds while providing the ability to visualize all other components
Mass range 30 to 1250 m/z
Scan speed Automatically-optimized for enhanced data quality for acquisition rates of up to e.g. 10Hz for m/z 100 to 1000 or 20 Hz for m/z 50 to 500
Mass accuracy Mass accuracy is better than ±0.2 Da over full mass range
Mass stability Mass drift is less than 0.1 Da over a 24 hour period
Linearity of response The linearity of response relative to sample concentration, for a specified compound,
is up to four orders of magnitude from the limit of detection
Ion polarity switching time 25 ms to switch between positive and negative ion modes
SIR acquisition rate Automatically-optimized for enhanced data quality for acquisition rates of up to 100Hz
Number of SIR channels Up to 1024 SIR channels (32 functions, 32 channels per function) can be monitored
in a single acquisition
Mass resolution Automated mass resolution control (0.7 Da) for constant data quality
SIR sensitivity (ESI+) A 100 pg on column injection (5 μL of 20 pg/μL) of sulfadimethoxine, with a mobile phase
flow rate of 800 μL/min will give a chromatographic signal-to-noise for m/z 311 greater than 2000:1 (400:1 with integrated diaphragm backing pump)
SIR sensitivity (ESI-) A 50 pg on column injection (5 μL of 10 pg/μL) of chloramphenicol, with a mobile phase
flow rate of 800 μL/min will give a chromatographic signal-to-noise for m/z 321 greater than 300:1 (60:1 with integrated diaphragm backing pump)
SIR signal-to-noise definition Signal is defined as the height of the chromatographic peak of interest and noise is
defined as the RMS of a continuous section of the mass chromatogram

It should be noted that the above are not standard installation specifications. All ACQUITY QDa Detectors will be installed and tested in accordance with standard performance tests as detailed in ACQUITY QDa Detector Installation Checklist. Test criteria are routinely reviewed to ensure quality is maintained and are therefore subject to change without notice. See Site Preparation Guide and Product Release Notes for additional product and specification information.


  • Model: ACQUITY QDa Mass Detector
  • Manufactured by: Waters