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Waters SQ Detector 2 Single Quadrupole Mass Detector

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SQ Detector 2

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Designed for the routine, prepared for the unexpected

The Waters™ SQ Detector 2 is an advanced bench top single quadrupole mass detector designed for high performance LC-MS applications. With a wide range of ionization options including Atmospheric Pressure Photo Ionization (APPI) and the Atmospheric Solids Analysis Probe (ASAP), the SQ Detector 2 is ideally suited to a wide range of qualitative and quantitative applications.

The system includes IntelliStart™ Technology, for automated system optimization and status monitoring, ensuring that the highest quality of data is routinely available to all levels of operators.

Compatible with the broadest range of chromatography platforms and ionization sources, the SQ Detector 2 is the ultimate single quadrupole mass detector for chromatography.

  • IntelliStart™ guarantees maximum system performance and usability for reproducible results
  • A wide mass range enables uncompromised analysis of both low and high molecular weight species
  • Versatile chromatographic options ensure compatibility with the broadest range of applications.
  • Universal Ion Source Architecture offers easy compatibility with the widest range of analytes

Mass Detection that's easy to live with

IntelliStart™ Technology automates system setup so that non-expert users can acquire data with confidence that the system is operating optimally. An integrated system of fluidics, electronics, and software which continually monitors system performance, helps you tune for optimum sensitivity, creates optimized SIR analysis methods and enables easy reporting of whole system performance. Through a series of diagnostic checks, the MS detector can report when it is ready for use. Any failures trigger a red-light system status, which warns that action may be required before analysis can proceed.

A mass range as wide as you would need

With a mass range of 3000 Da, the SQ Detector 2 makes mass confirmation of large molecules easier than ever before, allowing you to see higher mass peaks and giving you more confidence in your mass assignments.

Raw data for an intact antibody collected to m/z 3000.  When deconvoluted, MassLynx software shows the mass of the antibody to be 148kDa.

Versatile chromotography compatibility

Designed for optimum compatibility with multiple chromatographic separation techniques, the SQ Detector 2 is perfectly placed to help you extract more knowledge from your analyses. The SQ Detector 2 is compatible with UPLC, UPC2, HPLC, GC, preparative HPLC and preparative SFC, as well as direct analysis with the ASAP probe.

The SQ Detector 2 is compatible with UPLC, UPC2, HPLC, GC, preparative HPLC and preparative SFC, as well as direct analysis with the ASAP probe.

Future-proofing for the innovations of tomorrow

The universal ion source architecture of the SQ Detector 2 family allows the widest range of ionization techniques to be utilized as well as the very latest innovations in ionization technologies. You’ll have limitless choice in experimental options. When you need options and time is critical, the ion sources are quickly interchangeable and ready to use within minutes.

Walk-up accessibility

The OpenLynx™ Open Access Application Manager provides walk-up access for LC-MS operation in laboratories whose chemists have varying levels of instrumental analysis experience. OpenLynx also provides customizable batch processing to support the large amounts of data generated by high-throughput analyses. To accelerate the learning curve for instrument operation, OpenLynx leads you through sample submission, method selection, and reporting options. These routine analyses can be performed more efficiently when chemists submit their own samples, leaving instrumentation experts more time to focus on advanced analyses.

Accurate, reliable purification

FractionLynx™ Application Manager manages and automates your sample purification process. FractionLynx controls fraction collection and tracks your samples, their fractions, and associated data, all accessible through the FractionLynx browser. Offering flexible compound detection, fraction triggering and collection capabilities, you can tailor your purification system to your specific compound and laboratory needs utilizing several types of detection including MS, UV and ELSD, as well as various fraction triggering and collection options. FractionLynx is also compatible with OpenLynx Open Access to provide a simple walk-up purification solution.

ZSpray™ source architecture

Integral to the Universal Ionization Source, Waters’ patented ZSpray™ technology means that you get optimum performance and excellent reproducibility from your analysis. Providing exceptional resistance to contamination by involatile buffers, the unique dual orthogonal pathway gives superior separation of ions from neutrals, keeping the instrument cleaner for longer. This results in less down-time, higher laboratory efficiency, and better instrument utilization.

Waters proprietary Z-Spray source with the electrospray probe

Ensures the correct result every time

  • Prepare – IntelliStart™ and Quanpedia™ enable rapid, automated set-up and checking of the system and all of its methods, coupled with automatically scheduling MRM transitions to maximize performance. 
  • Analyze – During analysis, QCMonitor will actively monitor the data in real time, taking action if any user specified tolerances are exceeded. 
  • Interpret – TargetLynx provides automated quantification and reporting, with automated highly visible flags reducing the possibility for error. 
  • Decide –TrendPlot enables you to visualize results over many days, weeks or months; providing valuable information on data trends and long term system performance.

Specifications:

SYSTEM HARDWARE SPECIFICATIONS
API Sources and ionization modes

High performance ZSpray™ dual-orthogonal API sources:

  1. Multimode source - ESI/APCI/ESCi™ (standard) NB - Dedicated APCI requires an additional probe (optional)
  2. Dedicated APCI (optional)
  3. Dual mode APPI/APCI* source (optional)
  4. Atmospheric Solids Analysis Probe (ASAP) (optional)

Vacuum isolation valve
Tool free access to customer serviceable elements 
Plug and play probes
De-clustering cone gas 
Software control of gas flows and heating elements

Ion source transfer optics High efficiency stacked ring ion guide
Mass analyzer Single high resolution quadrupole analyzer, plus pre-filter to maximize resolution
and transmission while preventing contamination of the main analyzer
Detector Low noise, off axis, long life photomultiplier detector
Digital dynamic range up to 4 x 106
Vacuum system Single, split-flow air-cooled vacuum turbomolecular pump evacuating
the source and analyzer
One rotary backing pump
Dimensions Width: 36.0 cm (14.2 in.)
Height: 59.3 cm (23.4 in.)
Depth: 74.1 cm (29.2 in.)
Regulatory approvals/marks CE, CB, NRTL (CAN/US), RCM
SYSTEM SOFTWARE SPECIFICATIONS
Software Systems supported on MassLynx™ 4.1 and Empower 3 (and later versions)
IntelliStart Technology
  • System parameter checks and alerts
  • Integrated sample/calibrant delivery system + programmable divert valve Automated mass calibration
  • Automated sample tuning
  • Automated SIR method development
  • LC-MS system check - automated on-column performance test
Automated SIR scheduling* (acquisition rate assignment) Dwell time, inter-channel delay time, and inter-scan delay time for individual channels in a multiple SIR experiment can be automatically assigned (using the Auto-Dwell feature) to ensure that the optimal number of SIR data points per chromatographic peak is acquired. The Auto-Dwell feature can dynamically optimize SIR cycle times to accommodate
retention time windows that either partially or completely overlap. This greatly simplifies SIR method creation, irrespective of the number of compounds in a single assay, while at the same time ensuring the very best quantitative performance for every experiment.
Automated SIR scheduling* (acquisition window assignment) Multiple SIR experiments can be scheduled (manually or automatically using the
Quanpedia™ database) using retention time windows to optimize the cycle time for each SIR channel monitored. If required, SIR retention time windows can overlap partially or completely. This ensures that SIR data acquisition rates will be optimal for the quantification of all analytes in a given assay.
PERFORMANCE SPECIFICATIONS
Acquisition modes Full scan MS
Selected Ion Recording (SIR)
RADAR An information-rich acquisition approach that allows you to collect highly specific
quantitative data for target compounds while providing the ability to visualize all
other components
Mass range 2 to 3072 m/z
Scan speed Up to 15,000 Da/s
Examples of achievable acquisition rates:
15 scans per second (m/z 100 to 1000)
30 scans per second (m/z 50 to 500)
Mass stability Mass drift is less than 0.1 Da over a 24 hour period
Linearity of response The linearity of response relative to sample concentration, for a specified compound,
is four orders of magnitude from the limit of detection
Polarity switching time 20 ms to switch between positive and negative ion modes
ESCi mode switching time 20 ms to switch between ESI and APCI
SIR acquisition rate Minimum dwell time of 3 ms per SIR channel;
Minimum inter-channel delay of 3 ms
Number of SIR channels** Up to 16,384 SIR channels (512 functions, 32 channels per function) can be monitored
in a single acquisition; up to 1024 SIR channels when operating in GLP/secure mode
(32 functions, 32 channels per function)
Mass resolution Automatically adjusted (IntelliStart) to desired resolution
SIR sensitivity (ESI+) A 1 pg on column injection (5 μL of 0.2 pg/μL) of reserpine, with a mobile phase flow rate
of 400 μL/min will give a chromatographic signal-to-noise for m/z 609 greater than 150:1
SIR sensitivity (APCI+) A 1 pg loop injection (5 μL of 0.2 pg/μL) of reserpine, with a mobile phase flow rate of
1000 μL/min will give a chromatographic signal-to-noise for m/z 609 greater than 120:1
SIR signal-to-noise definition Signal is defined as the height of the chromatographic peak of interest and noise
is defined as the RMS of a continuous section of the mass chromatogram

* Feature is only available on systems controlled by MassLynx 4.1.
** 512 Function operation is only available with systems controlled by MassLynx 4.1. Empower 3 controlled systems monitor a maximum of 1024 SIR channels (32 function, 32 channels per function).


  • Model: SQ Detector 2
  • Manufactured by: Waters

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