Waters ACQUITY UPLC I-Class (SM-FL) System with Binary Solvent Manager (BSM) and Sample Manager with Fixed-Loop

ACQUITY UPLC I-Class (SM-FL) System

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Waters ACQUITY UPLC I-Class System (SM-FL) System with Binary Solvent Manager (BSM) and Sample Manager with Fixed-Loop

The Waters® ACQUITY UPLC® I-Class System’s holistic design is targeted for investigative analysis where maximized peak capacity, throughput, and sensitivity are critical and is perfectly suited for running any MS based application. The system is comprised of a Binary Solvent Manager (BSM) and a Sample Manager with Fixed-Loop (SM-FL); this design offers lowest dispersion performance and is suitable for running 1.0 mm columns. The ACQUITY UPLC I-Class System is available with a choice of column management options.

Complex chromatography challenges, solved

Looking for answers to the most complex scientific challenges is what you do, and the scientific tools you deploy and the information they provide can make all the difference. With industry-leading separations performance, the ACQUITY UPLC I-Class PLUS System provides new possibilities for maximizing the resolution and sensitivity of your methods, enhancing the characterization of your samples, and improving productivity to advance the science of your laboratory.

With the ACQUITY UPLC I-Class PLUS System, your lab can achieve highly efficient, rapid separations from industry-leading ultra-low dispersion and delay volume. The ACQUITY UPLC I-Class PLUS System enables your lab to get narrow, ultra-efficient peaks, enhancing the sensitivity of any mass spectrometer and simplifying the characterization of the most complex sample.

• Achieve precise and accurate binary solvent blending with the Binary Solvent Manager, ideal for up to four solvents with integrated solvent-select valve
• Get sample injection versatility, depending upon your application with the flow-through needle and fixed loop injector options
• Manage ultra-low carryover through programmable method settings to ensure compatibility even with the most sensitive mass spectrometers
• Get accurate temperature control across the entire column, configurable for 1 to 2 columns with active preheating
• Improve the performance of any mass spectrometer with the highest chromatographic resolution which minimizes interference from co-elutions
• Minimize the time and cost associated with annual qualification with the Waters Empower-based automated system qualification tool (SQT)
• Supported by Empower, Masslynx, UNIFI, and several third-party software packages

Recommended Use: Enhance the characterization of your samples, while improving productivity to advance the science of your laboratory.

Get a clearer picture of your sample

Get improved resolution through reduced system dispersion with the ACQUITY UPLC I-Class PLUS System, providing separations that can amplify your research.

Shorten analysis times, reduce solvent usage, and speed access to the data you need for critical decisions. Designed to fit into your existing LC workflow, the ACQUITY UPLC I-Class PLUS System provides a clear view into what lies within the sample.

In this example, the impurity analysis of tetracaine was run under the same conditions on the ACQUITY UPLC I-Class PLUS System (system band spread of 4 µL) and a UHPLC system (system band spread of 20 µL). Significantly better resolution was achieved on the ACQUITY UPLC I-Class PLUS System.

An inlet that improves the performance of any MS

The ACQUITY UPLC I-Class PLUS System is designed specifically for the rapid pace of laboratories on the cutting edge of research where LC-MS plays a critical role.

With the ACQUITY UPLC I-Class PLUS System, your lab will:

• Improve resolution and ionization efficiency with narrow peak widths, enhancing mass spectrometry sensitivity
• Enhance sensitivity through industry-leading carryover performance
• Improve sample characterization through selective isolation with multidimensional UPLC configurations
• Achieve exceptionally fast analysis times with ultra-low delay volume

A high sensitivity UPLC-MS/MS bioanalytical methodology for the quantification of midazolam and imipramine in rat plasma using the Xevo TQ Absolute Tandem Quadrupole Mass Spectrometer in combination with an ACQUITY UPLC I-Class PLUS System.

Achieve ultimate peak capacity with CORTECS Columns

When paired with CORTECS 1.6 µm solid-core columns, the ACQUITY UPLC I-Class PLUS System enables scientists to achieve new levels of resolution, sensitivity, and chromatographic performance. With CORTECS Columns and the ACQUITY UPLC I-Class PLUS System, you can increase resolution for even your toughest samples and get the flexibility and power you need to rapidly separate a wide array of compounds.

By pairing the ultra-low dispersion ACQUITY UPLC I-Class PLUS System with high-efficiency CORTECS Columns, you’ll achieve new levels of UPLC performance. These 1.6 µm columns deliver exceptional levels of efficiency, performance, and throughput, resulting in narrower peaks and higher peak capacity.