Waters SELECT SERIES MRT Multi Reflecting Time-of-Flight LC-MS/MS System

SELECT SERIES MRT

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All the benefits of time-of-flight technology. Redefined performance

Accelerate your research and comprehensively identify analytes in your complex samples with the SELECT SERIES MRT, built with state-of-the-art Multi Reflecting Time-of-Flight (MRT) technology.

• Identify sample components confidently with routine ppb mass accuracy 
• Resolve nominally isobaric interferences with high mass resolution, at all scan speeds
• Reveal isotopic fine structure for unambiguous elemental compositions
• Achieve high data quality in both MS and MS/MS
• Simplify data archiving and rapidly process data with reduced data files sizes.

High resolution mass spectrometry, without compromise

The SELECT SERIES MRT provides a unique combination of ultra-high resolution and specificity, independent of scan speed, resulting in unambiguous compound identification with even the most complex samples.

Distinguish the fine isotope structure of small molecules, resolve nominally isobaric interferences, and baseline resolve the isotopic envelope of multiply-charged ions with high resolution MRT technology. Unlike other high-resolution mass analyzers, with MRT there is no compromise to your experiments; mass resolution is consistent over a broad mass range and scan speeds.

The SELECT SERIES MRT achieves groundbreaking Time-of-Flight (ToF) resolution with the innovative use of multiple reflections of the ion beam between two gridless electrostatic mirrors in the mass analyzer. This extends the ions’ flight path, spatially refocusing the ion packets through a series of periodic lenses after each reflection maintaining sensitivity.

The superior performance of the SELECT SERIES MRT results in high precision and routine part-per-billion mass accuracy independent of acquisition speed, providing unsurpassed quality of mass spectrometry data and information. The instrument is operated via the SELECT SERIES MassLynx acquisition system with simple and intuitive experimental setup, acquisition, and processing of mass spectrometry data for imaging experiments. Data is recorded in the widely deployed Waters .raw file format, which can easily be accessed via the MassLynx API, exported as (i)mzML, and other interchangeable data formats, ready to use in your data analysis strategy

Faster analysis without compromise

There is a continuous drive for laboratories to increase productivity, the need for faster analysis has never been greater.  The use of shorter chromatographic columns and rapid gradients enable higher efficiencies, unlike other ultra-high resolution mass spectrometers the SELECT SERIES MRT addresses these challenges without compromising performance.  Resolution and mass accuracy are independent of scan speed, maintaining chromatographic fidelity at the fastest acquisition speeds, enabling accurate quantification.

Redefining confidence for LC-MS

The SELECT SERIES MRT provides a new level of confidence for LC/MS experiments by routinely obtaining ppb mass accuracy, revealing fine isotope structure, all with the exceptional usability of a state-of the-art Q-Tof.  The spectacular performance enables search tolerances to be minimized, providing higher confidence in elemental composition and molecular formula assignments for known and unknown targets.  Moreover, the ability to routinely access such high specificity from accurate mass for both precursor and product ions is truly transformative. 

Redefining clarity in mass spectrometry imaging

The SELECT SERIES MRT reduces analysis times by providing crystal clear, high-resolution images, acquired at fast imaging speeds without compromising mass spectral resolution or accuracy.

This enables accelerated mass spectrometry imaging experiments while still resolving analytes from interferences, revealing fine structural information. The cutting-edge technology and intuitive software combine to revolutionize mass spectrometry imaging for a wide range of applications; where the ability to map compounds that differ by only a few mDa is changing the pace of research. This includes:

• Tissue analysis in biomedical research
• Forensic research, including fingerprint analysis
• Surface analysis, ranging from surface contamination analysis for semiconductor production, to analysis of tape stripped skin samples in the cosmetics industry.

Maximize your mass spectrometry imaging capabilities and analytical flexibility with both DESI and MALDI on the SELECT SERIES MRT. This quadrupole time-of-flight mass spectrometer can be paired with either the DESI XS source or the high-performance SELECT SERIES MALDI source, so you can utilize Full Spectrum Molecular Imaging (FSMI) in your experiments.

The complementary nature of these techniques enables different molecules to be ionized on the same tissue surface, pinpointing the spatial localization of a wide range of biomolecules and pharmaceutical compounds as they are desorbed from tissue sections. This provides superior accuracy for compound identification.

Confident biolocalization and identification

The accompanying video shows the differential spatial distributions of seven distinct, clearly resolved ions, all contained within a <150mDa window, that are easily visualized from a mouse brain tissue section. Moreover, the accurate mass data can be database searched to provide accurate identifications.

DESI XS and the SELECT SERIES MRT

DESI XS produces high quality data allowing for clear visualization of molecular spatial distributions. The speed and versatility of DESI imaging makes it best suited to the analysis of lipids and other small molecules under ambient, direct analysis conditions, without the need for additional matrices.

The improved sensitivity, usability and robustness of DESI XS opens the possibility of mass spectrometry imaging to even more research laboratories, while the performance of the SELECT SERIES MRT ensures you can tackle the most challenging analytical problems with ease.

Redefining MALDI imaging

The new high-performance MALDI source for the SELECT SERIES MRT improves both imaging performance and ease-of-use, enabling large tissue sections to be rapidly imaged at high spatial resolution, with improved selectivity and sensitivity. The novel source design uses a tightly focussed laser beam profile, increasing signal-to-noise at high spatial resolutions and providing lateral resolution of 15µm without oversampling, in addition to data acquisition rates >10 pixels per second. These features enable high intensity images to be acquired quickly and efficiently.

• Seamlessly interchange between MALDI and DESI XS sources
• Enable imaging of large sections with a full-sized Micro Titre Plate (MTP) format MALDI target plate
• Access high spatial resolution through increased signal to noise (S/N), with a focused laser beam profile
• Simplify usability with an automated isolation valve and laser focus control
• Maximize productivity and uptime with easy cleaning and maintenance.