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Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometry Instrument

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Xevo TQ Absolute

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Absolute power to easily quantitate your most challenging compounds

Achieve absolute confidence to reach lower limits of quantitation even for challenging negative ionizing compounds with an instrument that delivers absolute performance – the Xevo TQ Absolute.

An incredibly compact, more sustainable tandem quadrupole mass spectrometer, the Waters Xevo TQ Absolute enables your lab to achieve and maintain high performance and productivity. With the Xevo TQ Absolute’s consistent robustness, significantly increased sensitivity for negative ionizing compounds compared to the previous product, and flexible software options, your lab can achieve time and cost savings with reproducible, complete results.

  • Absolute performance: Achieve lower limits of quantitation to meet regulatory requirements with up to 15x more sensitivity for challenging negative ionizing compounds than the previous product.
  • Absolute efficiency: Achieve improved environmental sustainability and lower your laboratory operational costs with an instrument that uses approximately 50% less electricity and gas and produces 50% less heat than most other high performance TQ mass spectrometry instruments on the market.
  • Absolute productivity: Boost your productivity with flexible software solutions, including waters_connect, the modern, intuitive  informatics platform that can save up to 50% of your data review time, while facilitating data integrity.
  • Absolute confidence: Ensure consistent robustness and reproducibility so you can maintain performance and productivity over a longer time period.

Recommended Use: Reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds.

Achieve absolute performance with improved sensitivity

To reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds, you need an instrument that delivers absolute performance. Xevo TQ Absolute delivers up to 15x better sensitivity for challenging negative ionizing compounds than the previous product, so you can make confident decisions, fast.

Improve sustainability and lower operational costs

Many businesses are trying to actively address environmental sustainability while also reducing operational costs. The Xevo TQ Absolute makes it possible to do just that. The Xevo TQ Absolute was developed to achieve lower electricity consumption, gas consumption, and BTU/hr output - lessening the need for air conditioning and lowering costs. The Xevo TQ Absolute also provides more analytical capability per square foot of lab space by minimizing the LC-MS/MS footprint, so laboratory managers can fully optimize their facilities and increase efficiency.

Xevo TQ Absolute provides significantly increased sensitivity, particularly for negative ion compounds such as polar pesticides.

Maintain peak performance longer with robustness and reproducibility

Analytical laboratories face a number of evolving challenges, so absolute confidence that your analytical instrumentation can keep pace is critical. The Xevo TQ Absolute has been specifically developed to deliver consistent robustness and reproducibility to maintain performance and productivity over a longer time period. Achieve the best performance while minimizing contamination and reducing the need for inconvenient downtime to clean the instrument with the Xevo TQ Absolute’s optimal probe positioning guidance. Your lab can also maximize uptime by minimizing contamination of the source from sample matrix or mobile phase salts with the Xevo TQ Absolute’s new source shield.

Ensure absolute productivity with flexible software options

Achieve the ultimate flexibility to choose the right solution for your lab with our flexible software options for quantitation - the waters_connect and MassLynx software platforms. Our modern, app-based software platform waters_connect delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time and ensures your lab is as productive as possible. Meanwhile, our tried, well-established MassLynx Software package delivers superior versatility and flexibility across all application areas.

Minimize contamination and increase uptime with the new source shield technology featured in the Xevo TQ Absolute.

Minimize contamination and increase uptime with the new source shield technology featured in the Xevo TQ Absolute.

Ensure absolute productivity with flexible software options

Achieve the ultimate flexibility to choose the right solution for your lab with our flexible software options for quantitation - the waters_connect and MassLynx software platforms. Our modern, app-based software platform waters_connect delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time and ensures your lab is as productive as possible. Meanwhile, our tried, well-established MassLynx Software package delivers superior versatility and flexibility across all application areas.

 

The unique functionality of waters_connect for quantitation ensures your Xevo TQ Absolute provides absolute productivity.

The unique functionality of waters_connect for quantitation ensures your Xevo TQ Absolute provides absolute productivity.

Specifications:

Hardware
API sources and ionization modes

High performance ZSpray dual-orthogonal API sources:

  1. Multi-mode source – tool free ESI/APCI/ESCi* (standard) NB – Dedicated APCI requires an additional probe (optional)
  2. UniSpray ion source (optional)
  3. Tool-free APCI probe (optional)
  4. nanoFlow™ ESI source* (optional)
  5. ASAP* (optional)
  6. APGC ion source* (optional)

Optimized gas flow dynamics for efficient ESI desolvation
Tool-free source exchange
Vacuum isolation valve
Tool-free access to user serviceable elements
Plug-and-play probes
De-clustering cone gas
Software control of gas flows and heating elements

UniSpray ion source option UniSpray is an ionization technique designed to broaden the scope of compounds which can be analyzed in a single run, including those which typically optimize in ESI, APCI or APPI. Enhanced ionization efficiency and desolvation allow the potential to combine several methodologies into one, or simply enable the operator to keep the same source for multiple methods, requiring less time performing set-up and routine maintenance, and more time delivering results
Ion source transfer optics

StepWave XS ion transfer optics delivering class leading UPLC™-MS/MS sensitivity.

The unique off-axis design and segmented quadrupole second stage dramatically increases the efficiency of ion transfer from the ion source to the quadrupole MS analyzer at the same time as actively eliminating undesirable neutral contaminants

Mass analyzer Two high-resolution, high-stability quadrupole analyzers (MS1/MS2), plus pre-filters to maximize resolution and transmission while preventing contamination of the main analyzers
Collision cell
  • T-Wave enabled for optimal MS/MS performance at high data acquisition rates;
  • Software programmable gas control
Detector Low-noise, off-axis, long-life photomultiplier XDR Detector
Vacuum system
  • One splitflow turbomolecular pump
  • One vacuum backing pump
Dimensions
  • Width: 43.0 cm (16.9 in.)
  • Height: 79.0 (31.1 in)
  • Depth: 96.0 (37.8 in)
Regulatory approvals/marks CE, CB, NRTL (CAN/US), RCM
Software
Software Systems supported on waters_connect and MassLynx version 4.2 or later
System setup and method development
  • System parameter checks and alerts
  • Integrated sample/calibrant delivery system + programmable divert valve Automated mass calibration
  • Automated sample tuning
  • Automated MRM method development
  • UPLC-MS/MS System Check – on-column performance test
Automated MRM scheduling (acquisition rate assignment) Dwell time, inter-channel delay time and inter-scan delay time for individual channels in a Multiple MRM experiment can be automatically assigned (using the Auto-Dwell feature) to ensure that the optimal number of MRM data points per chromatographic peak are acquired. The Auto-Dwell feature dynamically optimizes MRM cycle times to accommodate retention time windows that overlap. This greatly simplifies MRM method creation, irrespective of the number of compounds in a single assay, while at the same time ensuring the very best quantitative performance for every experiment
waters_connect Software The waters_connect Software provides a modern user experience with a HUB design and apps that provide a consistent connected user experience across all applications. It is built for applications with convenient access to scientific apps allowing accelerated time-to-results and result quality. There are common utilities that complete the end-to-end workflow and help increase productivity and efficiency. Confidently report results with accurate, reliable, regulation-standard data from application-focused quantitative workflows with built in traceability for utmost integrity.
Performance Capabilities
Acquisition modes
  • Full scan MS
  • Product ion scan
  • Precursor ion scan
  • Constant neutral loss scan
  • Multiple reaction monitoring (MRM) Simultaneous Full scan and MRM (RADAR)
RADAR An information rich acquisition approach that allows you to collect highly specific quantitative data for target compounds while providing the ability to visualize all other components
Mass range 2 to 2048 m/z

 


  • Model: Xevo TQ Absolute
  • Manufactured by: Waters