QLA Rotating Cylinder for Transdermal Patches, V Series, USP App 6 - APPSIX-VS

The rotating cylinder is very similar to USP method 1 (the rotating basket). With USP method 6 however, the basket assembly is replaced by a solid stainless steel cylinder.

The cylinder consists of two parts that fit together: the main shaft/cylinder assembly plus an extension. The extension is used when the transdermal patch requires a larger area.

Unlike dissolution testing, transdermal testing is carried out at 32°C to reflect the lower temperature of the skin. Other variables such as the height setting and sampling requirements are the same as dissolution testing.

The USP 6 rotating cylinder is similar to USP Method 1 (the rotating basket). With USP Method 6 however, the basket assembly is replaced by a solid stainless steel cylinder. The transdermal patch is fixed to the outside surface of the cylinder.Transdermal testing is carried out at 32°C to reflect the temperature of the skin. Other variables such as the height setting and sampling requirements are the same as for USP Method 1. 

This USP 6 apparatus is compatible with most brands of dissolution bath.

The Apparatus 6 Rotating Cylinder is used for testing Transdermal Patches in any standard Dissolution Test Station. The optional extension is used for larger patches. The extension easily connects to the cylinder with a precision frictional fit. The Rotating Cylinder is serialized. The extension is also serialized with a serial number which corresponds to the Rotating Cylinder serial number. The precision friction fit requires the Rotating Cylinder and optional Extension be purchased as a matched set.