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COSMOSIL SFC Columns

Supercritical Fluid Chromatography (SFC)

Supercritical Fluid Chromatography (SFC) has become more attractive because it offers some advantages over HPLC, such as high speed, unique selectivity and environmentally friendly separations. Many conventional normal-phase stationary phases, such as diol, amino and cyano, have been used for SFC applications. However, these phases present limitations for separations. COSMOSIL SFC Columns have been developed to enhance the capability of SFC separations.

Nacalai Tesque has developed columns specially designed for SFC in collaboration with Nacalai USA and Pfizer, Inc. Global R&D: COSMOSIL HP, PY (equivalent to 2-ethylpyridine) and Quinoline. In addition to these, our HPLC columns Cholester and PBr have been tested for use with SFC.

ProductStationary phaseFeatures
Category I: Columns for mid- to high-polarity compounds
For these compounds, a high-polarity stationary phase is suitable. More polar compounds are retained longer.
COSMOSIL PYPyridinylSimilar selectivity to 2-ethylpyridine; strong retention in general.
COSMOSIL HP3-HydroxyphenylDifferent selectivity from PY; strong retention for basic compounds.
COSMOSIL DiolDiolLess effect from ionic interaction.
Category II: Columns for low-polarity compounds
For these compounds, a low-polarity stationary phase is suitable.
COSMOSIL CholesterCholesterylLonger retention and better separation than C18.
Category III: Columns for SFC-specific separations
In supercritical fluid chromatography (SFC), secondary interactions such as π-π and dispersion force* are stronger compared to high-performance liquid chromatography (HPLC). As a result, these columns are capable of unique separations in SFC.
COSMOSIL πMAXPyrenylethylStronger π-π interactions than phenyl columns.
COSMOSIL PBrPentabromobenzylUnique separations using dispersion force.*

Dispersion force:
London dispersion force is a weak intermolecular force that results from dipoles temporarily induced from random unsymmetrical electron positions in two adjacent atoms, also known as "instantaneous dipole-induced dipole force". It is present in all molecules, regardless of whether they are polar or non-polar. Compounds with high polarizability have stronger dispersion force.

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COSMOSIL HP SFC Columns
COSMOSIL HP SFC Columns
COSMOSIL PY SFC Columns
COSMOSIL PY SFC Columns
COSMOSIL Diol SFC Columns
COSMOSIL Diol SFC Columns

COSMOSIL Cholester SFC Columns
COSMOSIL Cholester SFC Columns
COSMOSIL nMAX SFC Columns
COSMOSIL nMAX SFC Columns
COSMOSIL PBr SFC Columns
COSMOSIL PBr SFC Columns

COSMOSIL Quinoline SFC Columns
COSMOSIL Quinoline SFC Columns

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