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Nacalai Tesque Reagents, Standards, Solvents

Arg-SEC Mobile Phase

Size-Exclusion Chromatography (SEC) is an essential technology for developing biopharmaceuticals. SEC is normally carried out in aqueous solution so that the mobile phase has a minimal impact on the target biopharmaceutical proteins, e.g., not disrupting the protein structure. However, such mobile phase is not often optimal for the performance of SEC. Proteins often bind to the SEC column surface, leading to a compromised protein elution and peak resolution. Such binding can cause incorrect determination of the size of the eluted proteins and the amount of the aggregated species. To overcome these problems, arginine-based mobile phase*1 has been developed. This mobile phase reduces non-specific protein binding to many SEC columns, while not affecting the protein structure. Depending on the strength of non-specific binding, there are 3 mobile phases: strong, standard and mild.


 



Item Name Product Image Price

Nacalai Tesque COSMOSIL 140C18-PREP C18 Packing Material, 140 um, 100g - 37934-66

Nacalai Tesque COSMOSIL 140C18-PREP C18 Packing Material, 140 µm, 100g Product Number: 37934-66 COSMOSIL C18-PREP The large particle size C18 bulk materials are widely used for lab- to process-scale purifications. COSMOSIL offers three...
Nacalai Tesque COSMOSIL 140C18-PREP C18 Packing Material, 140 um, 100g - 37934-66
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Nacalai Tesque COSMOSIL 140C18-PREP C18 Packing Material, 140 um, 1kg - 37934-11

Nacalai Tesque COSMOSIL 140C18-PREP C18 Packing Material, 140 µm, 1kg Product Number: 37934-11 COSMOSIL C18-PREP The large particle size C18 bulk materials are widely used for lab- to process-scale purifications. COSMOSIL offers three...
Nacalai Tesque COSMOSIL 140C18-PREP C18 Packing Material, 140 um, 1kg - 37934-11
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Nacalai Tesque COSMOSIL 140C18-PREP C18 Packing Material, 140 um, 500g - 37934-95

Nacalai Tesque COSMOSIL 140C18-PREP C18 Packing Material, 140 µm, 500g Product Number: 37934-95 COSMOSIL C18-PREP The large particle size C18 bulk materials are widely used for lab- to process-scale purifications. COSMOSIL offers three...
Nacalai Tesque COSMOSIL 140C18-PREP C18 Packing Material, 140 um, 500g - 37934-95
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Nacalai Tesque COSMOSIL 40C18-PREP C18 Packing Material, 40 um, 100g - 37932-86

Packing Materials for Column Chromatography Nacalai Tesque COSMOSIL 40C18-PREP C18 Packing Material, 40 um, 100g Product Number: 37932-86 Open column chromatography is an excellent and easy technique for large-scale preparation and purification...
Nacalai Tesque COSMOSIL 40C18-PREP C18 Packing Material, 40 um, 100g - 37932-86
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Nacalai Tesque COSMOSIL 40C18-PREP C18 Packing Material, 40 um, 500g - 37932-15

Packing Materials for Column Chromatography Nacalai Tesque COSMOSIL 40C18-PREP C18 Packing Material, 40 um, 500g Product Number: 37932-15 Open column chromatography is an excellent and easy technique for large-scale preparation and purification...
Nacalai Tesque COSMOSIL 40C18-PREP C18 Packing Material, 40 um, 500g - 37932-15
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Nacalai Tesque COSMOSIL 75C18-PREP C18 Packing Material, 75 um, 100g - 37933-76

Nacalai Tesque COSMOSIL 75C18-PREP C18 Packing Material, 75 µm, 100g  Product Number: 37933-76 COSMOSIL C18-PREP The large particle size C18 bulk materials are widely used for lab- to process-scale purifications. COSMOSIL offers three...
Nacalai Tesque COSMOSIL 75C18-PREP C18 Packing Material, 75 um, 100g - 37933-76
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Nacalai Tesque COSMOSIL 75C18-PREP C18 Packing Material, 75 um, 1kg - 37933-21

Nacalai Tesque COSMOSIL 75C18-PREP C18 Packing Material, 75 µm, 1kg  Product Number: 37933-21 COSMOSIL C18-PREP The large particle size C18 bulk materials are widely used for lab- to process-scale purifications. COSMOSIL offers three...
Nacalai Tesque COSMOSIL 75C18-PREP C18 Packing Material, 75 um, 1kg - 37933-21
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Nacalai Tesque COSMOSIL 75C18-PREP C18 Packing Material, 75 um, 500g - 37933-05

Nacalai Tesque COSMOSIL 75C18-PREP C18 Packing Material, 75 µm, 500g Product Number: 37933-05 COSMOSIL C18-PREP The large particle size C18 bulk materials are widely used for lab- to process-scale purifications. COSMOSIL offers three...
Nacalai Tesque COSMOSIL 75C18-PREP C18 Packing Material, 75 um, 500g - 37933-05
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Nacalai Tesque COSMOSIL 75SL-II-PREP Spherical Packing Material, 75 μm, 1kg - 38012-51

COSMOSIL SL-II-PREP COSMOSIL SL-II-PREP is ultra pure silica gel packing material more than 99.99% purity. COSMOSIL SL-II-PREP provides improved separation and reproducibility for compounds with carbonyl or phenol hydroxyl groups, which are often...
Nacalai Tesque COSMOSIL 75SL-II-PREP Spherical Packing Material, 75 μm, 1kg - 38012-51
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Nacalai Tesque COSMOSIL 75SL-II-PREP Spherical Packing Material, 75 μm, 5kg - 38012-06

COSMOSIL SL-II-PREP COSMOSIL SL-II-PREP is ultra pure silica gel packing material more than 99.99% purity. COSMOSIL SL-II-PREP provides improved separation and reproducibility for compounds with carbonyl or phenol hydroxyl groups, which are often...
Nacalai Tesque COSMOSIL 75SL-II-PREP Spherical Packing Material, 75 μm, 5kg - 38012-06
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Nacalai Tesque COSMOSIL(R) 140C18-PREP 100G - 12063-04

COSMOSIL(R) 140C18-PREP
Nacalai Tesque COSMOSIL(R) 140C18-PREP 100G - 12063-04 £98.60Buy Now

Nacalai Tesque COSMOSIL(R) 140C18-PREP 1KG - 12063-91

COSMOSIL(R) 140C18-PREP
Nacalai Tesque COSMOSIL(R) 140C18-PREP 1KG - 12063-91
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Nacalai Tesque COSMOSIL(R) 140C18-PREP 500G - 12063-75

COSMOSIL(R) 140C18-PREP
Nacalai Tesque COSMOSIL(R) 140C18-PREP 500G - 12063-75 £493.97Buy Now

Nacalai Tesque COSMOSIL(R) 50C18-PREP 500G - 12065-55

COSMOSIL(R) 50C18-PREP
Nacalai Tesque COSMOSIL(R) 50C18-PREP 500G - 12065-55
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Nacalai Tesque COSMOSIL(R) 75C18-PREP 100G - 12061-24

COSMOSIL(R) 75C18-PREP
Nacalai Tesque COSMOSIL(R) 75C18-PREP 100G - 12061-24 £89.90Buy Now

Nacalai Tesque COSMOSIL(R) 75C18-PREP 1KG - 12061-11

COSMOSIL(R) 75C18-PREP
Nacalai Tesque COSMOSIL(R) 75C18-PREP 1KG - 12061-11 £497.84Buy Now

Nacalai Tesque COSMOSIL(R) 75C18-PREP 500G - 12061-95

COSMOSIL(R) 75C18-PREP
Nacalai Tesque COSMOSIL(R) 75C18-PREP 500G - 12061-95 £323.84Buy Now

Nacalai Tesque Silica Gel 120, spherical 1KG - 30734-41

Product Name: Silica Gel 120, spherical Amt: 1KG Product Code: 30734-41
Nacalai Tesque Silica Gel 120, spherical 1KG - 30734-41 £50.27Buy Now

Nacalai Tesque Silica Gel 500G - 17091-55

Product Name: Silica Gel Amt: 500G Product Code: 17091-55
Nacalai Tesque Silica Gel 500G - 17091-55 £11.60Buy Now

Nacalai Tesque Silica Gel 500G - 17092-45

Product Name: Silica Gel Amt: 500G Product Code: 17092-45
Nacalai Tesque Silica Gel 500G - 17092-45 £17.40Buy Now