Waters Arc Premier System with Binary Solvent Management

Arc Premier System with Binary Solvent Management

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See clearly and consistently, with confidence

Reduce non-specific adsorption from metal interactions in HPLC and UHPLC applications and obtain higher quality,…

Today’s scientists and lab managers need to confidently produce the most accurate, reliable, and reproducible data. The Arc Premier System produces correct, robust results from the very first injection, reliably and easily. 

The Arc Premier System features the new, innovative solution of MaxPeak High Performance Surfaces (HPS) Technology, which effectively reduces non-specific adsorption due to metal interaction — without complicated mobile phases or laborious methods. The Arc Premier System sharpens chromatographic peaks for metal-sensitive compounds by eliminating secondary interactions from metals, so you can:

• Support meeting compliance standards with higher quality data
• Achieve faster, more reproducible, and accurate data integration
• Shorten time from sample to result by eliminating the need for system conditioning

Available Options:

• Arc Premier System with Quaternary Solvent Management
• Arc Premier System with Binary Solvent Management
• Arc Premier 2998 PDA Detector
• Arc Premier 2475 Fluorescence Detector
• Arc Premier 2489 UV/Visible Detector

Overview

• See your sample clearly - Get the full picture of your sample with MaxPeak HPS Technology, which provides up to 10x improvements in assay-to-assay precision, up to 5x improvements in sensitivity, and 30% faster data processing for metal sensitive compounds.
• Flexibly blend multiple solvents - Blend from four up to nine solvents in any combination or proportion with multi-solvent blending with the Quaternary Solvent Manager (QSM). Blend accurately at a constant pressure of up to 9500 psi throughout the flow rate range with the Binary Solvent Manager (BSM-R).
• Get high-precision injections with direct inject sampling - The needle-in-flow path design ensures an accurate needle seal at high pressure for injection volumes from 0.1 μL up to 1 mL. Achieve ultra-low carryover (≤0.002%) through programmable method settings – for compatibility with even the most sensitive mass spectrometers.
• Achieve flexible, stable method development - Accommodate up to six columns ranging in length from 50 mm to 300 mm with a temperature range of 4 °C to 90 °C, with column manager options and optional and integrated column selection valves for fast, unattended column changeover. 
• Ensure stability for method transfers - Ensure method repeatability from lab to lab with stable, uniform temperature management with integrated active pre-heating options. Gradient SmartStart easily adjusts for system volume differences when transferring methods from an alternative LC system without alteration to the method table.
• Eliminate manual, error-prone mobile phase solution preparation - Directly program gradients in units of pH and ionic strength with Auto?Blend Plus Technology to vary composition in the smallest increments of pH, improve day-to-day repeatability, and eliminate time-consuming manual mobile phase solution preparation.

Recommended Use: For improving the peak shape and reproducibility of even the most challenging metal-sensitive compounds.

Gain control of the unpredictable

Non-specific adsorption of metal sensitive compounds is an unpredictable challenge, resulting in chromatography with large relative standard deviations (RSDs) and broad, overlapping peaks, which can be challenging to integrate quickly and be accurate consistently.

Designed with MaxPeak HPS technology and paired with MaxPeak Premier 2.5 um columns, the Arc Premier System improves data quality for challenging compounds, including metal-sensitive compounds tested with LC methods – so you can see clearly and consistently, with confidence.

Remove analytical uncertainty and increase data quality. This analysis shows adenosine, adenosine monophosphate, adenosine diphosphate, adenosine triphosphate on a conventional LC and the Arc Premier Solution.

Future-proof your lab for the next challenging compounds

Data quality and performance are critical for your lab, but those can’t come at the sacrifice of ruggedness and ease of use. Now you can future-proof your lab for the next generation of challenging compounds with MaxPeak HPS Technology, which sharpens peaks for metal-sensitive compounds for higher data quality and improved sensitivity with chromatographic reproducibility and precision. With MaxPeak HPS Technology and flexible LC performance, your lab gets the typical benefits of an LC system optimized for 2.5 – 3.5 µm column chemistry with the ability to shorten run times and achieve sharp peaks—no lengthy and complex conditioning and conditioning methodologies for metal-sensitive compounds required.

Sharpen peaks for higher data quality and improved sensitivity. This analysis shows hydrocortisone phosphate, betamethasone, dexamethasone phosphate, dexamethasone, and dexamethasone acetate on a conventional LC and the Arc Premier Solution.

Reduce analytical uncertainty and achieve peace of mind

With MaxPeak HPS Technology, metal-sensitive analytes become visible that were previously undetectable. This allows you to quickly and confidently know that you've seen everything in your sample, giving you the confidence to stand behind your data-driven decisions. The combination of MaxPeak HPS Technology, flexible pump and column management options, and precise optical and MS detection give you the method development and verification capabilities to know that no matter the sample – you can deliver a robust method you can stand behind.

By eliminating the need for time-consuming system passivation, your organization can both decrease the time to obtain results as well as reduce excessive mobile phase consumption. This gives your laboratory more confidence in meeting timeline, budgetary, and sustainability goals.

6 sets of 6 replicate injections on 6 Arc Premier Systems vs 6 sets of 6 replicate injections on 3 conventional LCs.

Reduce user errors, compliance issues, and expensive audits

With MaxPeak HPS Technology, metal-sensitive analytes become visible that were previously undetectable. This allows you to quickly and confidently know that you've seen everything in your sample, giving you the confidence to stand behind your data-driven decisions. The combination of MaxPeak HPS Technology, flexible pump and column management options, and precise optical and MS detection give you the method development and verification capabilities to know that no matter the sample – you can deliver a robust method you can stand behind.

By eliminating the need for time-consuming and error prone system passivation or conditioning that can introduce system-to-system variability, your organization can decrease the time to obtain results, excessive mobile phase consumption, and method transfer data repeatability problems. This gives your laboratory more confidence in meeting timeline, budgetary, and sustainability goals.

Integrate peaks more reproducibly and eliminate system conditioning effects and variability with the Arc Premier System. This data shows 6 users processing methods across 18 sets of 6 injections of hydrocortisone phosphate, betamethasone, dexamethasone phosphate, dexamethasone, and dexamethasone acetate on a conventional LC and the Arc Premier Solution.

Chromatograms of adenosine diphosphate and adenosine triphosphate at injection 1, 50, and 120.