Waters Alliance HPLC Dissolution System

Alliance HPLC Dissolution System

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Test with Confidence

The Waters® Alliance® HPLC Dissolution System is a High Throughput, automated, online HPLC platform for dissolution and drug release testing. The system automates the entire test: from dropping the dosage form that starts the test, to sample acquisition, analysis and calculation of the results to the management of report preparation and distribution. Sample aliquots are transferred from single or dual dissolution baths directly into covered vials held in the climate-controlled compartment of the Separations Module. Analysis of the sample, by either HPLC or Absorbance (flow injection), is synchronized with the time schedule for sample acquisition, minimising the total time required to complete the test and increasing your sample throughput. 

The Waters® Alliance® HPLC Dissolution System incorporates the e2695D Separations Module and up to two compatible dissolution baths. Empower™ based dissolution software provides complete automation from a single keyboard.

Key Features:

• High sample throughput
• Automated sample acquisition from a variety of dissolution baths
• Publication-quality report publisher
• custom dissolution calculations
• Fully compliance ready.
• Compatible with a variety of dissolution baths
• Advanced Solvent and Sample Management

The Alliance HPLC Dissolution System is the industry’s first HPLC platform that combines dissolution sample and HPLC analysis. The core of the system is the e2695D Separations Module, whose integrated fluidics design provides optimised control over the solvent and sample management processes, allowing you the flexibility to meet your specific requirements.

The low dispersion design and the capability of automatically conditioning and blending up to four eluents allows the system to be used with high efficiency columns, providing fast and accurate results for even your most complex formulations. Samples are processed individually or as pooled samples according to compendial procedures.

Methods are run by downloading sampling times and sample aliquot volumes to the Waters Transfer Module. The transfer modules use a microprocessor-controlled array of syringe pumps to take dissolution samples from six or eight vessels simultaneously and transfer the samples into sealed vials housed in the 2695D Separations Module.

Versatile media management

The system provides a few choices for media management to suit your specific dissolution testing needs. You can use the following capabilities singly or in combination.

• Recirculate - Recycles media used for rinsing the sample path to dissolution vessels prior to drawing sample, minimising media lost during a test. Useful in single-bath configurations.
• Rapid Sampling - Samples from a single bath, at shorter intervals, allowing for faster sample times
• Media replacement - The vessels from one or two baths are maintained at a constant volume using a fresh media reservoir.

High Sample Throughput

When you have many samples to analyse, multi-bath sampling offers the highest productivity and the most cost-effective operation. The Alliance Dissolution System allows you to acquire and process dissolution samples from up to two dissolution baths (six to eight vessels per bath).

Intuitive, easy-to-use interface

The easy-to-learn dissolution Sample Set Wizard allows you to enter all of your dissolution test parameters in a step-by-step fashion.

A FLEXIBLE, COST EFFECTIVE PLATFORM

Ultimate system flexibility
The Alliance HPLC Dissolutions System is based on the e2695D Separations Module, which has the same advanced analytical capabilities as the standard Alliance HPLC Systems. Therefore, this system can be sued alternative for both dissolution and/or HPLC analyses without re-configuring or re-learning.

Choice of analytical techniques

The system can be used as a common platform for both UV and HPLC based dissolution. This allows you to easily alternate between UV and HPLC analysis on the same sample set without having to repeat the dissolution test. In addition, common compliance tool and analysis calculations can be used for both platforms.

Choice of detection

No matter your analysis, the system can be used with whatever detection technique you require. Waters offers a full line of detector options, which can be used as stand alone or in series to fit your need for sensitive yet comprehensive dissolution analysis. Multi-detection can be useful for simultaneous analysis of actives or with compounds of vastly different physiochemical properties.

DO MORE WITH YOUR RESULTS

Waters software solutions enable you to capitalise on the results by the Alliance HPLC Dissolution System. The easy-to-use dissolution software seamlessly integrates with Empower Software and automates the entire dissolution process - from dissolution to sampling analysis calculation to reporting. Its built-in relational database gives you the power to organise, store and retrieve your data quickly and easily while also providing the flexibility to create a variety of searching, tracking, filtering and viewing criteria for enhanced productivity.

The Empower dissolution software is fully 21 CFR Part 11 compliant-ready. It electronically stores detailed audit reports, has high levels of security and assures the highest level of integrity for all your tests.