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Waters Xevo TQD Triple Quadrupole Mass Spectrometry Instrument

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Xevo TQD

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The rugged, robust and reliable Xevo TQD

The single vendor solution for routine quantitative UPLC-MS/MS applications, providing maximum accessibility to the sensitivity, selectivity and robustness needed to ensure maximum productivity with minimum effort.

  • Maximum uptime through unparalleled robustness.
  • Accelerated method development for sensitive and robust methods.
  • Reduces complexity, increases ease of use, and ensures the correct result every time.
  • Maximize throughput with no compromise on quality.
  • The widest range of ionization capabilities today, future-proofing for the innovations of tomorrow.

Maximum uptime through unparalleled robustness

Rapid round the clock analysis requires a reliable, robust system, capable of delivering the same result everytime.

Summary of 3357 on column injections of 1pg Verapamil in protein precipitated plasma

Understanding sample complexity

Some challenges for quantitative methods are:

  • Calculating compound concentrations in addition to the detection of unexpected contaminants.
  • Characterization of the background matrix for every sample, increasing data quality.
  • Detection of analytes that are not in a targeted multiple reaction monitoring (MRM) screening method.
  • Improving method development by discovering more matrix components.

 These challenges may be overcome by using RADAR which is the ability to obtain full scan (MS) and MRM (MS/MS) data simultaneously.

Product Ion Confirmation scanning (PICS) allows you to have full confidence in your results. Activated by a single check box in the method editor, PICS automatically triggers a product ion scan when a peak is detected by MRM.

 

RADAR data enables rapid decision making during sample clean-up method development

 

Ensures the correct result every time

Prepare – IntelliStart™ and Quanpedia™ enable rapid, automated set-up and checking of the system and all of its methods, coupled with automatically scheduling MRM transitions to maximize performance.

Analyze – During analysis, QCMonitor will actively monitor the data in real time, taking action if any user specified tolerances are exceeded.

Interpret – TargetLynx provides automated quantification and reporting, with automated highly visible flags reducing the possibility for error.

Decide –TrendPlot enables you to visualize results over many days, weeks or months; providing valuable information on data trends and long term system performance.

Maximize throughput with no compromise on quality

Accurate quantitation of the narrow peak widths typical of UPLC® (2 to 3 s) demands fast acquisition speeds to ensure data quality targets are achieved. The T-Wave collision cell ensures that the UPLC chromatographic speed and resolution benefits can be fully exploited, whether you are analyzing one compound, or hundreds of compounds, per method.

 

Signal intensity is maintained when the MRM dwell time is reduced from 100 ms to 3 ms

 

Ion source flexibility comes as standard

Universal ion source architecture ensures coverage of every application, with unlimited potential. The Xevo range of mass spectrometers all have multiple ion source options which are interchangeable in minutes and provide optimal ionization for each function required in the laboratory. The Xevo TQ-S micro may be used with ESI, ESCI, APCI, APGC, ASAP  and is also compatible with DESI (Prosolia), DART (IonSense) and LDTD (Phytronix) ion sources.

Pushing the boundaries – leading technology

The key technologies that enable you to do more with your instrument start with UniSpray™ which ionizes a wider range of compounds than any other single technique. Combining wider compound coverage with an extremely easy to use source, UniSpray can deliver results to your laboratory for more compounds than before, without having to change source or probe. So you can spend more time delivering results and less time changing instrument parts.

UniSpray UPLC/MRM data on the Xevo TQ-XS showing improved sensitivity for three compounds that typically optimize best on different ionization techniques

 


  • Model: Xevo TQD
  • Manufactured by: Waters