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Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometry Instrument

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 Xevo TQ-XS

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One system. Every analyte. All the time.

Demands on analytical laboratories are changing and every laboratory needs to ensure it can keep pace with these changes. The Xevo® TQ-XS offers:

  • StepWave XS™ ion guide that provides increased sensitivity for challenging compounds.
  • Enhanced detection system with six orders of linear dynamic range to ensure sensitivity is accessible.
  • Tool-free probe design reduces the time taken for any routine maintenance and provides improved reproducibility between users.

Reproducible, ultimate sensitivity quantitation

Whether you are analyzing small or large molecules, single analytes or multiple panels of compounds, the Xevo TQ-XS will give you the results you need, first time and without complication.

The new StepWave XS ion guide provides improved sensitivity that is reproducible for multiple injections and can provide reliable quantitation at the very lowest levels. StepWave XS ensures neutrals and gas load are passively removed for enhanced transmission, with the ions actively transferred into the mass analyser, improving sensitivity and robustness. The first stage is modified with a series of horizontal plates that allows a more controlled extraction of ions from the gas flow so that ions collide with gas molecules with less energy.

A segmented quadrupole second stage focuses the ion beam to provide more efficient transmission of ions from the source to the detector.

Greater sensitivity for a number of compounds using UPLC/MRM with ESI.

Pushing the boundaries – leading technology

The key technologies that enable you to do more with your instrument start with UniSpray™ which ionizes a wider range of compounds than any other single technique. Combining wider compound coverage with an extremely easy to use source, UniSpray can deliver results to your laboratory for more compounds than before, without having to change source or probe. So you can spend more time delivering results and less time changing instrument parts.

UniSpray UPLC/MRM data on the Xevo TQ-XS showing improved sensitivity for three compounds that typically optimize best on different ionization techniques

Robust results you can trust with the most demanding sample matrices

The routine challenges of complex matrices are overcome by the Xevo TQ-XS which provides reproducible results injection after injection despite difficult sample matrices. In a study involving 2,000 injections of protein-precipitated plasma and analyzing sulphadimethoxine, there was little variation in peak area over the entire injection series with <3% RSD. This study aimed to reproduce the challenging conditions found in many analytical laboratories by also using a short dwell time of only 5 ms.

2,000 injections of sulphadimethoxine in protein precipitated plasma with 2.55% RSD

Tool –free probe optimization and maintenance

Redefine the way that you operate your instrument with the new atmospheric pressure ionization probes available on the Xevo TQ-XS. You don’t need to worry about time-consuming optimization steps with any tools. Even changing the probe assembly including the capillary is entirely tool-free. Ensure that you get the same results no matter who operates and maintains the instrument probes, for improved reproducibility over much longer periods of time.

Routine maintenance of the ESI and APCI probes has never been so easy

Making sensitivity accessible with the Xtended Dynamic Range detector

When you need to measure analytes at very different concentrations within the same sample, it is very time-consuming to dilute samples and re-inject in a separate experiment to bring values within calibration curves. With the Xtended Dynamic Range (XDR™) detector there are now six orders of linear dynamic range, enabling you to quantitate a wider range of analyte concentrations without saturating the detector in a single injection.

Flexible quantitative software options to fit your needs

The Xevo TQ-XS is now available on waters_connect, Waters flagship software platform, so you can ensure your lab is as efficient as possible, whatever your application.

waters_connect   
Our new, modern, app-based software platform delivers unique efficiency and usability benefits so your lab can maximize productivity.

MassLynx
This well-established software package for all application areas delivers the versatility and flexibility your lab needs to succeed.

Comprehensive and streamlined results review with TargetLynx XS software which flags any results outside user-defined tolerances

 


  • Model: Xevo TQ-XS
  • Manufactured by: Waters