Waters BioAccord LC-MS System for Biopharmaceuticals

BioAccord LC-MS System for Biopharmaceuticals

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The First SmartMS-Enabled Biopharma Solution

The BioAccord LC-MS System is the first SmartMS-enabled biopharmaceutical solution. This compact, self-optimizing system has a built-in health check that ensures the system is always generating data of the required quality.

The simplicity provided by SmartMS means that the BioAccord generates the same high-quality results whether you are an LC-MS expert or a new user.

Robust and Reproducible

Rigorous validation of the complete solution has been implemented during the development and manufacture of the system with extended testing across multiple systems. The tests comprise complete biopharmaceutical methods, from sample to reported result, with application-relevant acceptance criteria that meet biopharmaceutical industry standards.

The BioAccord LC-MS System is operating in academic, biopharmaceutical and contract laboratories worldwide, generating consistent and reproducible results every day.

Data Quality

Customer feedback highlighted the need for a small, simple LC-MS system that generates the highest possible data quality.

The BioAccord was developed to meet these requirements, while also delivering the chromatographic resolution, mass resolution, sensitivity, mass accuracy and linearity to meet the needs for a wide range of routine biopharmaceutical analyses.

Chromatogram shows total ion chromatograms (TICs) overlay from 18 injections of the Waters mAb Tryptic Digest Standard (NISTmAb tryptic digest) offers reproducible chromatographic separation for peptides using shallow gradient method.

Addressing Your Applications

Whether your work involves analyzing biomolecules at the intact, subunit, peptide, or released glycan level, the BioAccord System comes with optimized compliance-ready workflows so you can get up and running right away. These include:

• Intact mass analysis of proteins and oligonucleotides
• Subunit analysis of monoclonal antibodies (mAbs)
• Peptide mapping/MAM (multi-attribute method)
• Released N-glycan analysis

Optimized workflows for released glycan analysis include our RapiFluor-MS label, which offers unparalleled fluorescense and MS sensitivity for accurate glycan profiling.

Compliance

Although the system can be used easily in research and early development environments, it has all the tools for adoption by the demanding regulatory environments of late development and QC.

Waters has provided LC and MS solutions for regulated laboratories for many years. Building on this expertise, the BioAccord is the first truly compliance-ready LC-MS system.

With a complete audit trail, configurable access controls and the protection of an Oracle database this system has everything you need to ensure data integrity and meet 21 CFR part 11 and Annex 11 requirements.

The waters_connect informatics platform that automates data acquisition, processing and reporting benefits from decades of industry leadership in developing compliance-ready informatics with Empower and UNIFI.

Productivity

The BioAccord System is designed to give you maximum productivity from your investment. With its SmartMS features, optimized workflows, and application specific release testing, the BioAccord System empowers users of all abilities to run routine biopharmaceutical analyses so your ms experts can focus on the research and discovery work they do best.

Our outcome-based services, which include application specific installation and training from our professional services team, are designed to get you quickly up and running so you can start generating results sooner.