Waters BioAccord LC-MS System with ACQUITY Premier for Routine Biotherapeutic Analysis

BioAccord LC-MS System with ACQUITY Premier for Routine Biotherapeutic Analysis

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BioAccord LC-MS System with ACQUITY Premier

The BioAccord LC-MS System with ACQUITY Premier is designed specifically for routine monitoring in biopharmaceutical process and product development.

• Rapid and confident decisions driven by accessible, high quality data
• Simplicity, consistency and productivity ensured by automation
• Relevant information provided by biotherapeutic analysis workflows and methods
• Compliant-ready platform that can be deployed from discovery to GxP labs
• Rapid deployment and return on investment
• Small system footprint

Why Adopt LC-MS

• Productivity is increased as a range different analyses can be performed on the same system, replacing multiple conventional analytical techniques
• Multi-attribute methods can be deployed that reduce the number of analyses required to monitor biotherapeutic quality
• It is a sensitive technique that allows detection of low level analytes and impurities
• It provides information-rich data that helps guide decision-making

Delivering Consistent, High Quality Data

Fully automated system set-up and an intelligent health system that continuously monitors system performance ensure that: 

• The system is always producing data of the required quality
• Data quality is consistent from user to user and system to system
• Any issues are rapidly diagnosed and resolved

This gives confidence that decisions are always being made based on good data and ensures productivity by maximising system uptime and minimising reanalysis.

How Good Is The Data?

Efficient separation is achieved using ultraperformance liquid chromatography (UPLC) enhanced by unique MaxPeak High Performance Surfaces (HPS) developed for the ACQUITY Premier UPLC system and columns. These deliver:

• High sensitivity for challenging acidic peptides
• High sensitivity for acidic glycans
• Higher sensitivity and higher productivity for oligonucleotide analysis by removing the need for passivation

MS data are generated using the ACQUITY RDa high resolution mass detector which was designed to deliver the required performance for biotherapeutic monitoring.

In head-to-head test in customer laboratories the ACQUITY RDa has been shown to give equivalent results to larger, higher cost and more complex advanced characterization systems for the relative quantification of peptide attributes.

Rapid Deployment And Return On Investment

The BioAccord LC-MS System with ACQUITY Premier is a complete system that has called on Waters’ core competencies of: 

• Chromatography systems
• Mass spectrometry
• Chemistry
• Informatics and compliance
• Service and application training / support

It is delivered as a complete system.  Installation is performed with application-specific specification tests. This is followed by training by our professional services team with methods and training material for biopharmaceutical analysis.

?The BioAccord LC-MS System with ACQUITY Premier is easily deployed in non MS expert environments, with no need to reinvent routine labs organization and headcount.

Keep Your Organization Connected

To maintain data integrity the system operates on the compliant-ready waters_connect informatics platform which allows BioAccord Systems to be networked.

?Information and data continuity across the organization can be ensured as BioAccord shares a common informatics platform with our Q-Tof LC-MS/MS systems. Advanced characterization and routine analysis systems can be connected on the same network allowing seamless access of methods and data.