Welcome, Sign In
Email:

Password:

Forgotten Password
Create Account
First time visitor? Create a New Account
Advanced Search
Your cart is empty 		Checkout

Waters SFC Prep 150 Mgm System

Price:
Live chat below or contact us for latest price.


Download Data Sheet

SFC Prep 150 Mgm System

Please contact our Sales Team for a quote.

A greener approach to high-throughput purification

Many of today’s laboratories are looking to adopt a greener approach to high throughput purification. Designed for high-throughput, semi-prep to preparative scale purifications, the SFC Prep 150 Mgm System is made for repeat injection (bulk purification) of chiral and achiral compounds.

The SFC Prep 150 Mgm System operates at flow rates higher than traditional high-performance liquid chromatography (HPLC) systems without significant increases in back pressure – allowing for high-speed supercritical fluid chromatography (SFC) purification, improved resolution of compounds, and higher purity isolations.

Key Features:

  • Achieve high-speed SFC purification and improved resolution of compounds, leading to higher purity isolations
  • Reduce normal-phase solvent usage and disposal
  • Benefit from increased usability with the new intuitive graphical interface of Chromscope 2.1 SFC Software supported by Windows 10
  • Achieve faster equilibration, lower pressure drops across the column, solvent reduction, and lower cost per sample with Waters SFC Prep 150 Mgm

Recommended Use: For laboratories seeking to adopt a greener approach to high-throughput purification.

A greener approach to high-throughput purification

The Waters SFC Prep 150 Mgm System is perfectly suited for laboratories seeking to adopt a greener approach to high throughput purification. The SFC Prep 150 Mgm System is the ideal choice when reduction of normal-phase solvent usage and disposal is a critically important step for purification laboratories wanting to become more environmentally friendly.

SFC systems utilize liquid carbon dioxide (CO2) as its main mobile phase in combination with one or more organic solvents, resulting in faster equilibration, lower pressure drops across the column, solvent reduction, and lower cost per sample. The process is reproducible and applicable to a wide range of compounds relevant in the pharmaceutical, life sciences, chemical materials food, and environmental markets.

Achieve higher purity isolations

The SFC Prep 150 Mgm System has a maximum flow rate, CO2 and co-solvent combined, of up to 150 mL/minute allowing use of 19 mm and 30 mm columns. It also has capacity for six fraction collection positions (two liters each).

The user can take advantage of a new intuitive graphical interface controlled by the Waters ChromScope 2.1 SFC Software supported by Windows 10. The SFC Prep 150 Mgm System operates at flow rates higher than traditional HPLC systems without significant increases in back pressure, allowing for high-speed SFC purification and improved resolution of compounds, leading to higher purity isolations. ChromScope v2.1 is an updated version of ChromScope Software that enables support of the Waters SFC Prep 150 Mgm System with the ACQUITY QDa Mass Detector. Additionally, this update adds support for ELSD and the Isocratic Solvent Manager.

Example ChromScope v2.0 chromatogram of 10 stacked injections at 306 nm to show maximum detection of 4-nitrophenol. The peak of interest is highlighted in green with a collection time of 21 seconds.

Example ChromScope v2.0 chromatogram of 10 stacked injections at 306 nm to show maximum detection of 4-nitrophenol. The peak of interest is highlighted in green with a collection time of 21 seconds.

System features that support increased throughput

The SFC Prep 150 Mgm System is designed to improve productivity with a greener approach to high-throughput purification, with features like:

  • QGM Quaternary Gradient Pump:  This pump delivers flowrates up to a maximum of 150 mL/min serves as the co-solvent delivery device for this system.
  • P200X CO2 Pump:  This high-pressure delivery pump has dual stainless-steel heads with a cam driven sapphire piston assembly; self-priming check valves; pressure sensor; pressure gauge; brushless motor, and a rupture disc assembly. The pump is designed to improve performance with feedback from the pressure sensor and mass flowmeter.
  • Modifier Stream Injector: Designed to support customer requests for modified-stream injection, this device injects one sample at a time using a standard 2 mL loop and a 5 mL syringe. This allows for settable air gaps on either side of the sample, which function as a buffer between the solvent and the sample, decreasing dilution.   
  • Prep Collection Cabinet: This collection cabinet comes with a retractable front door allowing for easy insertion and removal of 2 liter fraction bottles. The collection cabinet has an exhaust port in the upper backside of the cabinet to easily fit laboratories around the world, and comes standard with a removable spill tray. 
  • Effortless integration with the ACQUITY QDa Mass Detector: The intuitive design of the ACQUITY QDa Mass Detector provides the additional data you need without the cost and complexity of traditional mass spectrometry systems and software, giving you the analytical confidence that the selectivity of mass detection brings to your analysis.

ACQUITY QDa Detector.

ACQUITY QDa Detector.

Specifications:

System Features
Operating flow rate range 20 to 150 mL/min, combined CO2 and co-solvent
Maximum operating pressure 4350 psi (300 bar)
Recovery >90% (within total flow rate range)
*Individual component specifications may allow operation outside the total system defined parameters. The system is designed and tested only for the ranges defined in system specifications.
P200X Pump
Ambient operating temperature 15 to 40 °C
Ambient operating humidity 20 to 80% RH at 40 °C (104 °F)
Pressure rating 10,000 psi
Max operating pressure 8700 psi
Flow range 20 to 200 g/min
Wetted materials 316 stainless-steel, 440C, 17–4PH stainless-steel, sapphire, GFPM, PTFE, AL
Co-Solvent Pump (QGM)
Number of solvents
(Co-solvent pump only)		 Four solvents on the Solvent Select Valve (SSV)
Solvent conditioning
(Co-solvent pump only)		 Sparging one channel per solvent
Operating flow rate range 0.50 to 150.00 mL/min, in 0.01 mL/min increments
Maximum operating pressure 6000 psi up to 100 mL/min, roll off to 5000 psi at 150 mL/min
Operating flow rate range 0.50 to 150.00 mL/min, in 0.01 mL/min increments
Plunger seal wash Integral, active, programmable
Delay volume <6.5 mL
Compressibility compensation Automatic and continuous
Priming Self prime from solvent container on floor with dry lines
Compositional accuracy +/-3% absolute (full scale) from 5% to 95%; and from 1 to 150 mL/min
Compositional precision Retention time variation <0.15 min SD (uracil/caffeine; 1, 5, 20, 50, 150 mL/min; 70:30 water/methanol dial-a-mix)
Modifier Stream Injector
Default syringe 5 mL
Default loop size 2 mL (Optional; 5 mL, and 10 mL)
Injection volume range 0.010 mL (10 µL) to 9.5 mL (9500 µL)
Sample delivery precision Less than 1.0% RSD; 0.75 mL injection volume, 2.0 mL loop
Injection linearity R2 greater than 0.995 using 20–75% of loop volume (2 mL loop)
Sample carryover No Ketoprofen detected, therefore carry over is less than 0.01%
Primary wetted materials 316 stainless-steel, PEEK, PTFE, borosilicate glass
Fraction Selector
Number of fractions 1–6 fractions and 1 waste
Wetted material 316 stainless-steel, PEEK
Gas Liquid Separator (GLS)
Total flow range 20–150 mL/min
Co-solvent max flow rate 75 mL/min
Operational pressure range
(Optimal)		 0–100 psi
50 psi
Max pressure 100 psi
Wetted materials 316 stainless-steel, PEEK, borosilicate glass
ABPR-200
Max pressure 4400 psi
Ambient operating temperature 15 to 40 °C
Ambient operating humidity 20 to 80% RH at 40 °C (104 °F)
Wetted materials 316 stainless-steel, carbon filled PEEK, platinum, Teflon™ PTFE (Polytetrafluoroethylene)
GLS Make-up Pump
Max pressure 1600 psi
Ambient operating temperature 4–40 °C
Flow rate range 0.0–40.0 mL/min
Wetted materials Synthetic ruby, sapphire, UHMWPE, PTFE, stainless-steel
Heat Exchanger
Ambient operating temperature 15 to 40 °C
Ambient operating humidity 20 to 80% RH at 40 °C (104 °F)
Pressure rating 10,000 psi
Wetted materials 316 stainless-steel
2998 PDA Detector
Wavelength range 190 to 800 nm
Light source Prealigned, Intelligent Technology Deuterium D2 lamp
Wavelength accuracy ±1.0 nm
Linearity range <5% at 2 AU (Propylparaben 257 nm, 10 mm cell)
Optical resolution 1.2 nm
Noise, wet ≤60 μAU (254 nm, 2 Hz, 1 s TC, 3.6 BW res, 10 mm analytical cell)
Drift, dry ≤5000 μAU/h (2 h warm-up, constant temp. and humidity at 230 nm, 3.6 BW res, 2 Hz)
Data rate Up to 80 Hz
Path length 3 mm (semi-prep flow cell)
Cell volume 18.3 μL (semi-prep flow cell)
Pressure limit 6000 psi
Wetted materials 316 stainless-steel, PEEK, fused silica
Line voltage 100 to 240 VAC
Physical Characteristics
  Dimensions: D x W x H Weight: lbs
Modifier stream injector 14.4" x 12.4" x 11.5" 18.0 lbs
Prep fraction selector 14.7" x 9.2" x 6.6" 14.1 lbs
Gas-liquid separator 6.5" x 6.5" x 14.5" 2.6 lbs
ABPR 17.5" x 6.9" x 6.0" 16.0 lbs
P200X 24" x 14.3" x 12.3" 84.0 lbs
Heat exchanger 20" x 4.4" x 4.6" 12.8 lbs
Instrument Control
External control ChromScope 2.1
External communications Ethernet and RS-232 communications
Event input/outputs Rear panel contact closure and/or TTL inputs/outputs
Operating system Windows 10
Power Requirements
Voltage range Frequency VA Fuse
Modifier stream injector 240 50 200      F3A/250 V
Prep fraction selector 240 50 200      F3A/250 V
ABPR 240 50 200      F3A/250 V
P200X 240 50 200      F3A/250 V
Heat exchanger 240 50 1000    F3A/250 V
Make-up pump 240 50 220      F3A/250 V
2998 PDA detector 240 50      185      F3.15A/250 V
Julabo chiller 240 50      425      F3.15A/250 V
2545 QGM pump 240 50     650      F6.5A/250 V


  • Model: SFC Prep 150 Mgm System
  • Manufactured by: Waters

Product 5/7

Previous
Return to the Product List
Next
Desktop Version
© 2025 UVISON Technologies Limited. All rights reserved  |  Registered in England and Wales under company number 4718736 and VAT number GB 702 1041 10
wabusiness template