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Imtakt Cadenza CL-C18 MF 2mm ID, 30mm Length, 3um,ODS,Controlled end-Capping, Metal-Free Column - CL021F

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Cadenza CL-C18 Silanol-regulated C18

Cadenza CL-C18 MF 3µm 30mm x 2mm, 120Å  (ODS controlled endcapping) Metal-Free Analytical Column, Pressure limits of up to : 20MPa, 250 bar, 3,000 psi

Imtakt Product Number CL021F

Column Specifications:

Base Material: Silica
Quantity: 1 piece
Chemistry: C18 (RP-18, ODS, Octadecyl)
Manufacturer Chemistry Name:  CL-C18
Endcapping: controlled endcapping
Matrix: Silica
Brand: Imtakt Cadenza
Internal Diameter: 2 mm 
Length: 30 mm 
Particle Morphology: spherical, porous
Particle Size: 3 µm
Pressure Stability: up to 250 bar
Pore Size: 120 Å
Technology: HPLC Metal-Free
USP Class: L1

World’s First Silanol Regulated ODS Phase

The Cadenza family of columns is a high quality series of ODS columns with a ligand density optimized for steric selectivity. These powerful columns are able to distinguish subtle differences in your analytes making it an excellent choice for isomer separation, or detection of impurities. These columns have low back pressure due to the high quality of materials used in their manufacturing. With a unique polymeric end-capping these columns will also provide very little unwanted secondary interactions and better peak shape.

  • Unique ligand density provides excellent steric selectivity
  • World’s first silanol-regulated ODS phase provides additional selectivity options for ionic compounds
  • High efficiency 3µ ODS column with low back-pressure
  • HT and UP hardware able to operate in pressures up to 1000 bar

Due to its partial endcapping, the Cadenza CL-C18 opens a new world of separation possibilities. Almost all recent ODS columns have complete endcapping. However, complete endcapping makes some separations impossible. Conversely, ODS columns without any endcapping provide poor elution characteristics due to the influence of silanol. Our new Cadenza CL-C18 with partial encapping uniquely optimizes the remaining silanol. The difference between Cadenza CL-C18 and CD-C18 is that CL-C18 has more silanol remaining on the material surface. An example of the retention activity for an ionized compound (imazalil, pKa=ca.6) is pictured (above left) and shows the influence on eluent separation and retention of CL-C18’s remaining silanol. Imazalil retention is greatest with columns that are not endcapped, followed by CL-C18, and CD-C18, in that order.

Cadenza CL-C18 Metal-free HPLC Columns

Improving peak shape for chelating or phosphoric compounds

2 mm I.D. - 30-250 mm Length - PEEK / SS316 - UHPLC compatible

  • Metal-free (PEEK) internal structuren 
  • UHPLC compatible metal housing
  • Ideal for chelating compounds
  • Ideal for phosphoric compounds
  • LC-MS compatible 2mm I.D.
  • Wide selection of stationary phases

This metal-free column is an Imtakt original design. The entire internal surface of these columns are made with PEEK material, including the frits, and is therefore extremely inert with respect to chelating compounds. The outer portion of these columns are made from stainless steel (SS316) making them suitable for extremely high pressures, and are UHPLC compatible. 

Phosphoric compounds can interact with the exposed metal surfaces within the column causing peak tailing, as seen in the figure to the left.

Imtakt's metal-free columns are designed to specifically improve these poor peak shapes by decreasing unwanted secondary chelating effects.

Improving peak shape of chelating or phosphoric compounds
Chelating and phosphoric compounds often have difficulty with poor peak shape and/or sensitivity due to undesired interaction between metal parts in the column and the structure of these compounds. Imtakt's UHPLC compatible metal-free columns, which are an Imtakt original design, will improve these
problems and are available in a wide range of stationary phases.

Range of Cadenza CL-C18 Columns, Product Numbers:

Column Length (mm) Analytical Semi-prep
1.0 mm I.D. 1.5 mm I.D. 2.0 mm I.D. 3.0 mm I.D. 4.6 mm I.D. 6.0 mm I.D. 10.0 mm I.D.
3µm Columns, Pressure limits of up to: 20MPa, 250 bar, 3,000 psi
10     CL020 CL030 CL000    
20     CL029 CL039 CL009    
30 CL011 CL071 CL021 CL031 CL001 CL061 CL0P1
50 CL012 CL072 CL022 CL032 CL002 CL062 CL0P2
75 CL013 CL073 CL023 CL033 CL003 CL063 CL0P3
100 CL014 CL074 CL024 CL034 CL004 CL064 CL0P4
150 CL015 CL075 CL025 CL035 CL005 CL065 CL0P5
250 CL016 CL076 CL026 CL036 CL006 CL066 CL0P6
500         CL007    
3µm Columns, Pressure limits of up to: 50MPa, 500 bar, 7,500 psi
10     CL020T CL030T CL000T    
20     CL029T CL039T CL009T    
30 CL011T CL071T CL021T CL031T CL001T    
50 CL012T CL072T CL022T CL032T CL002T    
75 CL013T CL073T CL023T CL033T CL003T    
100 CL014T CL074T CL024T CL034T CL004T    
150 CL015T CL075T CL025T CL035T CL005T    
250 CL016T CL076T CL026T CL036T CL006T    
3µm UHPLC (UP) Columns, Pressure limits of up to : 100MPa,1000 bar, 15,000 psi
30     CL021U        
50     CL022U        
75     CL023U        
100     CL024U        
150     CL025U        
250     CL026U        
3µm Metal-Free Columns, Pressure limits of up to: 20MPa, 250 bar, 3,000 psi
30     CL021F        
50     CL022F        
75     CL023F        
100     CL024F        
150     CL025F        
250     CL026F        

Column Guard System for Cadenza CL-C18

Product Number Product Name Description
GCCL0C Guard Cartridge CL-C18 3um,ODS,Controlled end-Capping (5x1mm), 3pcs
GCCL0M Guard Cartridge CL-C18 3um,ODS,Controlled end-Capping (10x8mm), 2pcs
GCCL0S Guard Cartridge CL-C18 3um,ODS,Controlled end-Capping (5x2mm), 3pcs
GCH01S Guard Holder Guard Holder for 1-6mmI.D. separation columns
GCH02M Guard Holder Guard Holder for 10-20mmI.D. separation columns
GCH11S Guard Holder Guard Holder for 4.6mm column, enclosed an U-Shape column coupler
GCH12M Guard Holder Guard Holder for 10-20mm column, enclosed an U-Shape column coupler

All stationary phases can also be made in the following internal diameters, please contact our Sales Team with your specificatons: Nano: 0.02mm, 0075mm | Capillary: 0.1mm, 0.3mm, 0.5mm | Semi-Prep: 20mm, 28mm

This Column is also available in 5 µm!

Additional Imtakt Columns Available


  • Model: CL021F
  • Manufactured by: Imtakt

Additional Images