Nacalai Tesque COSMOSIL 2.5Cholester Analytical SFC Column, 2.5 µm, 130 Å, 2.1 x 150 mm, 1/Pk - 13752-31

Supercritical Fluid Chromatography (SFC) - 2.5Cholester (Cholesteryl)

Nacalai Tesque COSMOSIL 2.5Cholester Analytical SFC Column, 2.5µm, 130Å, 2.1mm I.D. x 150mm Length, 1/Pk

Product Number: 13752-31

Longer retention and better separation than C18

Supercritical Fluid Chromatography (SFC) has become more attractive because it offers some advantages over HPLC, such as high speed, unique selectivity and environmentally friendly separations. Many conventional normal-phase stationary phases, such as diol, amino and cyano, have been used for SFC applications. However, these phases present limitations for separations. COSMOSIL SFC Columns have been developed to enhance the capability of SFC separations.

Nacalai Tesque has developed columns specially designed for SFC in collaboration with Nacalai USA and Pfizer, Inc. Global R&D: COSMOSIL HP, PY (equivalent to 2-ethylpyridine) and Quinoline. In addition to these, our HPLC columns Cholester and PBr have been tested for use with SFC.

Cosmosil® Cholester Columns

Cholester is a silica-based reversed-phase column using cholesterol as the bonded phase. It has similar hydrophobicity to C18 (ODS) and, with superior stereoselectivity, it is suitable for compounds with similar hydrophobicity but slightly different molecular shape. Our COSMOSIL series features many packing materials, such as πNAP, NPE, PYE and PBr, that can separate compounds difficult to separate using ODS. However, these materials utilize several kinds of molecular interaction, so it is necessary to reconsider analysis conditions. Designed for ease of use, Cholester can be used under solvent and other analytical conditions identical to ODS.

• Better selectivity for cis-trans isomers, polyphenols, and natural products
• Cholesterol-bonded reversed-phase column
• Usable under the same conditions as C18 columns
• Available particle sizes: 5 μm, 2.5 μm, 2.6 μm core-shell

COSMOSIL SFC Column Series

• 2.5Cholester - 2.5 µm UHPLC Column
• 3Cholester - 3 µm HPLC Column
• 5Cholester - 5 µm HPLC Column

Column Specifications:

Additional Column Sizes are available - Please contact our Sales Team with your requirements.

Cosmosil Columns Online Catalogue:

• Nacalai Tesque COSMOSIL HPLC Columns
• Nacalai Tesque COSMOCORE UHPLC Columns
• Nacalai Tesque Reagents, Standards, Solvents