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Nacalai Tesque COSMOSIL 2.5Cholester Analytical SFC Column, 2.5 µm, 130 Å, 2.1 x 150 mm, 1/Pk - 13752-31

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Supercritical Fluid Chromatography (SFC) - 2.5Cholester (Cholesteryl)

Nacalai Tesque COSMOSIL 2.5Cholester Analytical SFC Column, 2.5µm, 130Å, 2.1mm I.D. x 150mm Length, 1/Pk

Product Number: 13752-31

Longer retention and better separation than C18

Supercritical Fluid Chromatography (SFC) has become more attractive because it offers some advantages over HPLC, such as high speed, unique selectivity and environmentally friendly separations. Many conventional normal-phase stationary phases, such as diol, amino and cyano, have been used for SFC applications. However, these phases present limitations for separations. COSMOSIL SFC Columns have been developed to enhance the capability of SFC separations.

Nacalai Tesque has developed columns specially designed for SFC in collaboration with Nacalai USA and Pfizer, Inc. Global R&D: COSMOSIL HP, PY (equivalent to 2-ethylpyridine) and Quinoline. In addition to these, our HPLC columns Cholester and PBr have been tested for use with SFC.

Cosmosil® Cholester Columns

Cholester is a silica-based reversed-phase column using cholesterol as the bonded phase. It has similar hydrophobicity to C18 (ODS) and, with superior stereoselectivity, it is suitable for compounds with similar hydrophobicity but slightly different molecular shape. Our COSMOSIL series features many packing materials, such as πNAP, NPE, PYE and PBr, that can separate compounds difficult to separate using ODS. However, these materials utilize several kinds of molecular interaction, so it is necessary to reconsider analysis conditions. Designed for ease of use, Cholester can be used under solvent and other analytical conditions identical to ODS.

  • Better selectivity for cis-trans isomers, polyphenols, and natural products
  • Cholesterol-bonded reversed-phase column
  • Usable under the same conditions as C18 columns
  • Available particle sizes: 5 μm, 2.5 μm, 2.6 μm core-shell

COSMOSIL SFC Column Series

Packing materialPYHPDiolCholesterπMAXPBr
Silica gelHigh-purity porous spherical silica
Average particle size3, 5 µm5 µm5 µm5 µm5 µm
Average pore size 120Å
Stationary phasePyridinyl3-HydroxyphenylDiolCholesterylPyrenylethylPentabromobenzyl
Endcapping treatmentNear-Perfect Treatment

Available in the Following Configurations:

  • 2.5Cholester - 2.5 µm UHPLC Column
  • 3Cholester - 3 µm HPLC Column
  • 5Cholester - 5 µm HPLC Column

Column Specifications:

Product descriptionCosmosil® 2.5Cholester Packed Column (for SFC) 2.1mmx150mm
Number / Quantity1 pc
ManufacturerNacalai Tesque
Brand nameCosmosil
Product typeSFC Column
length150 mm
inner diameter2.1 mm
Particle size2.5 µm
modificationCholesterol
Modification (manufacturer)Cholester
Pore size130 Å
USP ClassL101
Carbon content20.0%
Specific surface area [m2/g]330.0
Column typeAnalytical Column
Hardware materialstainless steel
Hardware TypeReady-to-use column
pH minimum2.0
pH maximum7.5
Separation technologySupercritical Fluid Chromatography (SFC)
technologySFC
matrixSilica
Particle morphologyspherical, fully porous

 

Additional Column Sizes are available - Please contact our Sales Team with your requirements.

Cosmosil Columns Online Catalogue:


  • Model: 13752-31
  • Manufactured by: Nacalai Tesque