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Imtakt Cadenza 5CX-C18 4mm ID, 250mm Length, 5um,ODS, Polar End-Capping - 5CX046

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Cadenza 5CX-C18 Polar End-Capping ODS Column

Cadenza 5CX-C18 Polar End-Capping 250mm x 4mm, 5μm, 120Å, Analytical HPLC Column, Pressure limits of up to: 20MPa, 250 bar, 3,000 psi

Imtakt Product Number 5CX046

Column Specifications:

Base Material: Silica
Quantity: 1 piece
Chemistry: C18 (RP-18, ODS, Octadecyl)
Manufacturer Chemistry Name:  5CX-C18
Endcapping: Polar End Capping
Matrix: Silica
Brand: Imtakt Cadenza
Internal Diameter: 4 mm 
Length: 250 mm 
Particle Morphology: spherical, porous
Particle Size: 5 μm
Pressure Stability: up to 250 bar
Pore Size: 120 Å
Technology: HPLC
pH: 2-10
MW: up to 10 kDa
USP Class: L1

High steric selectivity and molecular recognition C18 column for general use, ideal for separation of
isomers and other difficult to separate compounds. Polar end-capping technology provides a more complete coverage of surface silanols and unique selectivity.

Conventional ODS columns, including hybrid-silica type columns, require extensive end-capping in order to decrease residual silanols, which may negatively affect peak shape for basic compounds. Traditionally, this end-capping process has used methyl silane compounds which have a mild hydrophobic interaction. Viewing this interaction in terms of reversed-phase mode, the surface of the stationary phase presents two very different kinds of hydrophobic structures, octadecyl ligands (C18) and the methyl end-capping. These different hydrophobicities may provide an inconsistent response against a solutes interaction with the stationary phase, resulting in poor peak shape and reduced plate counts. Instead of relying on traditional end-capping with trimethyl silane (TMS) compounds, we have succeeded to develop a revolutionary surface modification technology using alcohol structures, which has been adapted to our brand new Cadenza CX-C18. This means that electrostatic interaction from the polar end-capped surface and hydrophobic interaction from the C18 ligand will localize the polarity of the surface and increase the recognition power of a complex compounds hydrophobic/hydrophilic structure. Therefore, Cadenza CX-C18 will have an alternative selectivity for certain compounds and possibly improved peak shape compared to conventional end-capped ODS columns.

  • Imtakt's first column featuring modified alcohol polar end-capping
  • Nearly 100% coverage of active surface silanol sites
  • Reduces tailing for basic compounds in acidic conditions
  • Alternative selectivity from traditional C18 columns
  • High steric selectivity and molecular recognition
  • Ideal for difficult isomer or impurity separations

Range of Cadenza 5CX-C18 Columns, Product Numbers:

Column Length (mm) Analytical Semi-prep Prep
1.0 mm I.D. 1.5 mm I.D. 2.0 mm I.D. 3.0 mm I.D. 4.0 mm I.D. 4.6 mm I.D. 6.0 mm I.D. 10.0 mm I.D. 20.0 mm I.D. 28.0 mm I.D.
5µm Columns, Pressure limits of up to: 20MPa, 250 bar, 3,000 psi
30 5CX011 5CX071 5CX021 5CX031   5CX001 5CX061 5CX0P1    
50 5CX012 5CX072 5CX022 5CX032   5CX002 5CX062 5CX0P2 5CX0Q2  
75 5CX013 5CX073 5CX023 5CX033   5CX003 5CX063 5CX0P3    
100 5CX014 5CX074 5CX024 5CX034   5CX004 5CX064 5CX0P4 5CX0Q4  
150 5CX015 5CX075 5CX025 5CX035 5CX045 5CX005 5CX065 5CX0P5 5CX0Q5  
250 5CX016 5CX076 5CX026 5CX036 5CX046 5CX006 5CX066 5CX0P6 5CX0Q6 5CX0R6

Column Guard System for Cadenza 5CX-C18:

Product Code Product Name Product Description
G5CX0C Guard Cartridge 5CX-C18 5um,ODS, Polar End-Capping (5x1mm), 3pcs
G5CX0M Guard Cartridge 5CX-C18 5um,ODS, Polar End-Capping (10x8mm), 2pcs
G5CX0S Guard Cartridge 5CX-C18 5um,ODS, Polar End-Capping (5x2mm), 3pcs
GCH01S Guard Holder Guard Holder for 1-6mmI.D. separation columns
GCH02M Guard Holder Guard Holder for 10-20mmI.D. separation columns
GCH11S Guard Holder Guard Holder for 4.6mm column, enclosed an U-Shape column coupler
GCH12M Guard Holder Guard Holder for 10-20mm column, enclosed an U-Shape column coupler

All stationary phases can also be made in the following internal diameters, please contact our Sales Team with your specificatons: Nano: 0.02mm, 0075mm | Capillary: 0.1mm, 0.3mm, 0.5mm | Semi-Prep: 20mm, 28mm

This column is also available in particle size 3µm!

Additional Imtakt Columns Available


  • Model: 5CX046
  • Manufactured by: Imtakt

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